396728-22-6

Basic information

• Product Name: N-α-fluorenylmethoxycarbonyl-N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide
• Synonyms: N-α-fluorenylmethoxycarbonyl-N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide
• CAS NO: 396728-22-6
• Molecular Weight: 1018.46
• Mol File: 396728-22-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-α-fluorenylmethoxycarbonyl-N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-α-fluorenylmethoxycarbonyl-N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide(396728-22-6)
• EPA Substance Registry System: N-α-fluorenylmethoxycarbonyl-N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide(396728-22-6)

Safety Data

• Hazardous Substances Data: 396728-22-6(Hazardous Substances Data)

Upstream product

• 75618-27-8 lauryl triflate 
• 112-53-8 1-dodecyl alcohol 

Downstream Products

• 396728-24-8 N^G-4-methoxy-2,3,6-trimethylbenzenesulfonyl-L-arginine(2,3-dilauryloxy)propylamide 

Relevant articles and documents

Synthesis of novel cationic lipids: Effect of structural modification on the efficiency of gene transfer

A series of novel cationic lipids was designed and synthesized in an effort to understand the importance of the various structural features with respect to transfection efficiency. Particular attention has been paid to the hydrophobic domain and the cationic headgroup. An efficient method of synthesizing asymmetric diether lipids is described, using alkyl chains ranging from C12 to C18 and the unsaturated oleyl group. The ternary formulations including the diether lipid 3β-[N-(N′,N′-dimethylaminoethyl)carbamoyl]cholesterol (DC-Chol) and dioleoyl phosphatidylethanolamine (DOPE) were up to 10-fold more efficacious in in vitro assays than the DC-Chol/DOPE control. The shorter and most asymmetric diether lipids performed the best. The chemical nature and basicity of the headgroups have been varied by the coupling of the four naturally occurring amino acids with cationic side chains-arginine, histidine, lysine, and tryptophan. Transfection efficiency was highest for arginine/lysine derivatives, with binary formulations containing the amino acid derivative alone and DOPE proving superior.