39679-94-2Relevant academic research and scientific papers
Aromatic-carbohydrate interactions: An NMR and computational study of model systems
Vandenbussche, Sophie,Diaz, Dolores,Fernandez-Alonso, Maria Carmen,Pan, Weidong,Vincent, Stephane P.,Cuevas, Gabriel,Canada, Francisco Javier,Jimenez-Barbero, Jesus,Bartik, Kristin
, p. 7570 - 7578 (2008)
The interactions of simple carbohydrates with aromatic moieties have been investigated experimentally by NMR spectroscopy. The analysis of the changes in the chemical shifts of the sugar proton signals induced upon addition of aromatic entities has been interpreted in terms of interaction geometries. Phenol and aromatic amino acids (phenylalanine, tyrosine, trypto-phan) have been used. The observed sugar-aromatic interactions depend on the chemical nature of the sugar, and thus on the stereochemistries of the different carbon atoms, and also on the solvent. A preliminary study of the sol_vation state of a model monosaccharide (methyl β-galactopyranoside) in aqueous solution, both alone and in the presence of benzene and phenol, has also been carried out by monitoring of intermolecular homonuclear solvent-sugar and aromatic-sugar NOEs. These experimental results have been compared with those obtained by density functional theory methods and molecular mechanics calculations.
Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties
Andreeva, Olga V.,Belenok, Maya G.,Saifina, Liliya F.,Shulaeva, Marina M.,Dobrynin, Alexey B.,Sharipova, Radmila R.,Voloshina, Alexandra D.,Saifina, Alina F.,Gubaidullin, Aidar T.,Khairutdinov, Bulat I.,Zuev, Yuriy F.,Semenov, Vyacheslav E.,Kataev, Vladimir E.
supporting information, (2019/11/05)
A series of novel 1,2,3-triazolyl nucleoside analogues was synthesized via the CuAAC reaction of N1-alkynyl uracil, 6-methyluracil, 3,6-dimethyl uracil, thymine and quinazolin-2,4-dione with protected azido β-D-ribofuranose. The obtained compounds differ in both the nature of the pyrimidine-2,4-dione fragment and the length of the polymethylene linker connecting it with the β-D-ribofuranosyl-1,2,3-triazol-4-yl moiety. The 1,2,3-triazolyl nucleoside analogues were evaluated for their cytotoxicity in vitro.
