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N-(2-amino-4-methylphenyl)-4-methylbenzenesulfonamide, also known as sulfamethoxypyridazine or sulfadoxine, is a synthetic sulfonamide antibiotic with antiprotozoal properties. It is primarily used in combination with pyrimethamine for the treatment and prevention of malaria caused by Plasmodium falciparum. The chemical structure consists of a sulfonamide group attached to a 4-methylbenzenesulfonamide moiety, which is further connected to a 2-amino-4-methylphenyl group. Sulfadoxine works by inhibiting dihydropteroate synthase, an enzyme involved in the synthesis of folic acid, which is essential for the growth and reproduction of the malaria parasite. Its effectiveness is enhanced when combined with pyrimethamine, which inhibits dihydrofolate reductase, another enzyme in the folic acid synthesis pathway. However, the emergence of drug-resistant strains of Plasmodium falciparum has limited the use of sulfadoxine-pyrimethamine combinations in some regions.

3968-01-2

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3968-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3968-01-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,6 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3968-01:
(6*3)+(5*9)+(4*6)+(3*8)+(2*0)+(1*1)=112
112 % 10 = 2
So 3968-01-2 is a valid CAS Registry Number.

3968-01-2Relevant academic research and scientific papers

A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

Fang, Shuai,Niu, Xiaoyi,Zhang, Zeyuan,Sun, Yan,Si, Xiaomeng,Shan, Cuicui,Wei, Lei,Xu, Aiqing,Feng, Lei,Ma, Chen

, p. 6895 - 6900 (2014/09/30)

A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed. Fluoro-, bromo- and nitro-substituted aryl aldehydes were applied to this reaction efficiently. This journal is the Partner Organisations 2014.

Palladium-catalyzed intramolecular sulfonamidation/oxidation of imines: Access to multifunctional benzimidazoles

Fu, Shaomin,Jiang, Huanfeng,Deng, Yuanfu,Zeng, Wei

experimental part, p. 2795 - 2804 (2011/12/01)

O-Sulfonamidophenylimines undergo intramolecular sulfonamidation/oxidation to produce 1,2-disubstituted benzimidazoles upon treatment with palladium(II) chloride/(diacetoxyiodo)benzene and potassium carbonate at room temperature. The substituent scope at

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