39684-28-1

Basic information

• Product Name: O-TERT-BUTYLHYDROXYLAMINE HYDROCHLORIDE
• Synonyms: O-T-BUTYLHYDROXYLAMINE HYDROCHLORIDE;O-TERT-BUTYLHYDROXYLAMINE HYDROCHLORIDE;O-Tert-ButylhydroxylamineHCl;O-(tert-Butyl)hydroxylamine hydrochloride,99%;2-Aminooxy-2-methylpropane hydrochloride;O-(1,1-Dimethylethyl)hydroxylamine hydrochloride;tert-Butoxyamine hydrochloride;HydroxylaMine,O-(1,1-diMethylethyl)-, hydrochloride (1:1)
• CAS NO: 39684-28-1
• Molecular Formula: C₄H₁₂NO*Cl
• Molecular Weight: 125.6
• EINECS: 254-590-1
• Product Categories: Hydroxylamines;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 39684-28-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 158-159 °C(lit.)
• Boiling Point: 110°Cat760mmHg
• Flash Point: 17.5°C
• Appearance: white-off solid or colorless liquid
• Density: g/cm³
• Vapor Pressure: 24.2mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: H2O: soluble0.5g/10 mL
• BRN: 3668106
• CAS DataBase Reference: O-TERT-BUTYLHYDROXYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-TERT-BUTYLHYDROXYLAMINE HYDROCHLORIDE(39684-28-1)
• EPA Substance Registry System: O-TERT-BUTYLHYDROXYLAMINE HYDROCHLORIDE(39684-28-1)

Safety Data

• Hazard Codes: F
• Statements: 11
• RIDADR: UN 1325 4.1/PG 3
• WGK Germany: 3
• F: 10
• HazardClass: 4.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 39684-28-1(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

Different sources of media describe the Uses of 39684-28-1 differently. You can refer to the following data:
1. Reactant involved in synthesis of biologically active molecules including:? ;CGS 25966 derivatives for use as MMP inhibitors1? ;Imidazolidinedione derivatives for use as antimalarial treatments2? ;Pyrimidine ribonucleotide analogs as P2Y6 receptor agonists3? ;Rab proteins for isoprenylation and geranylgeranylation inhibition4Reactant involved in:? ;Synthesis of N-(arylethyl)-O-tert-butylhydroxamates for use as Weinreb amide equivalents5? ;Double allylic alkylation of indole-2-hydroxamates6? ;SN2 substitution reactions at amide nitrogens7? ;Photoc
2. O-tert-Butylhydroxylamine Hydrochloride is an reactant used in various synthesis of biologically active molecules such as camptothecin derivatives that exerts anti-tumor activity, oxime derivatives as GPR119 agonists and their preparation and highly Potent Matrix Metalloproteinase Inhibitors.
3. Reactant involved in synthesis of biologically active molecules including:CGS 25966 derivatives for use as MMP inhibitorsImidazolidinedione derivatives for use as antimalarial treatmentsPyrimidine ribonucleotide analogs as P2Y6 receptor agonistsRab proteins for isoprenylation and geranylgeranylation inhibitionReactant involved in:Synthesis of N-(arylethyl)-O-tert-butylhydroxamates for use as Weinreb amide equivalentsDouble allylic alkylation of indole-2-hydroxamatesSN2 substitution reactions at amide nitrogensPhotocycloaddition to C=N bonds for synthesis of 1,3-diazepines

InChI:InChI=1/C4H11NO.ClH/c1-4(2,3)6-5;/h5H2,1-3H3;1H

Upstream product

• 51951-30-5 2-(tert-butoxy)isoindoline-1,3-dione 

Downstream Products

• 155388-59-3 2-hydroxy-5-nitro-N-tert-butoxyphenylacetyl amide 
• 162405-17-6 N-tert-Butoxy-2-(4-chlorphenyl)-2-hydroxypropanamid 
• 191228-69-0 O-tert-butyl-3-(4-iodophenoxy)propanohydroxamic acid 
• 191228-67-8 O-tert-butyl 5-(4-iodophenoxy)pentanohydroxamic acid 
• 297758-16-8 2-chloro-1-phenyl-ethanone O-tert-butyl-oxime 
• 477908-24-0 N-(tert-butyloxy)-2(R)-[[(2-nitrophenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide 
• 477908-26-2 (R)-2-(4-nitrophenylsulfonamido-N-(pyridin-3-ylmethyl))-N-tert-butyloxy-3-methylbutanamide 
• 477908-25-1 N-(tert-butyloxy)-2(R)-[[(3-nitrophenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide 
• 253155-02-1 C₃₅H₃₄Cl₂N₂O₅ 
• 885060-53-7 2-(3-azidopropyl)-N-tert-butoxy-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-carboxamide 
• 161315-09-9 N-(t-butyloxy)-2(R)-[[4-methoxybenzenesulfonyl](benzyl)amino]-6-[(N,N-dimethylglycyl)amino] hexanamide 

Relevant articles and documents

A facile synthesis of (tert-alkoxy)amines

Tertiary alcohols react with stoichiometric BF3?Et 2O and N-hydroxyphthalimide to yield N-alkoxyphthalimides. Subsequent hydrazinolyses afford the title compounds.

Sterol derivatives and its preparation method and application

The invention discloses a sterol derivative of beta-sitosterol, beta-stigmasterol and cholesterol, and is shown as a formula VI. The invention also discloses a preparation method of the sterol derivative. The invention also discloses application of the sterol derivative to the aspect of preparation of wound healing promoting medicine. By starting from easily obtained natural products, the beta-sitosterol, the beta-stigmasterol and the cholesterol are used as starting raw materials; the synthetic method is simple; better operability and reaction yield are realized. The prepared sterol derivative has the obvious wound healing promoting activity; the multiplication, migration and collagen synthesis capability on L929 mechanocytes is obviously higher than that of the raw material and positive control medicine recombinant human bFGF (basic fibroblast growth factor). Compared with protide type medicine (such as bFGF), the prepared sterol derivative has more diversified dosage forms and medication modes; the reference is provided for the application in the field of wound healing promoting. The formula VI is shown as the accompanying diagram.

On the origins of diastereoselectivity in the alkylation of enolates derived from N-1-(1′-Naphthyl)ethyl-O-tert-butylhydroxamates: Chiral Weinreb amide equivalents

(Chemical Equation Presented) The stereochemical outcome observed upon alkylation of enolates derived from N-1-(1′-naphthyl)ethyl-O-tert- butylhydroxamates (chiral Weinreb amide equivalents) may be rationalized by a chiral relay mechanism. Deprotonation withKHMDS leads to a nonchelated (Z)-enolate inwhich the oxygen atoms adopt an anti-periplanar conformation. The configuration of the N-1-(1′-naphthyl)ethyl group dictates the conformation of the O-tert-butyl group and the configuration adopted by the adjacent pyramidal nitrogen atom. Highly diastereoselective enolate alkylation then proceeds anti to both the bulky tert-butyl group (sterically driven) and the N-lone pair (stereoelectronically driven).