39695-74-4Relevant academic research and scientific papers
FUNCTIONALIZATION OF AROMATIC COMPOUNDS BY NUCLEOPHILIC SUBSTITUTION OF A HYDROGEN ATOM BY THE PHENYLACETONITRILE CARBANION
Orlov, V. Yu.,Kotov, A. D.,Bystryakova, E. B.,Kopeikin, V. V.,Mironov, G. S.
, p. 1481 - 1484 (2007/10/02)
Aromatic nitro compounds containing a substituent at the para react with phenylacetonitrile in an alcohol solution of alkali with the formation of 2,1-benzisoxazoles.The CH3, NH2, OH, and certain other substituents prevent the reaction.In the reaction of benzonitrile and phthalonitrile with phenylacetonitrile in the sodium hydroxide-DMSO system substitution of a hydrogen atom at the ortho position to the nitrile group is observed; the products from substitution of a hydrogen atom were not obtained in the reaction of phenylacetonitrile with aromatic nitriles containing other substituents.
