3970-41-0Relevant articles and documents
Synthesis of 2-N-alkyl(aryl)amino-7-nitrobenzothiazoles
Huang, Shenlin,Connolly, Peter J.
, p. 9373 - 9375 (2004)
A highly efficient synthesis of 2-N-alkyl(aryl)amino-7-nitrobenzothiazoles has been developed. The key step involves intramolecular cyclization of a thiourea facilitated by the nitro group. A highly efficient synthesis of 2-N-alkyl(aryl)amino-7-nitrobenzothiazoles has been developed. The key step involves intramolecular cyclization of a thiourea facilitated by the nitro group.
Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors
Wei, Wei,Zhou, Shaa,Cheng, Dandan,Li, Yuxin,Liu, Jingbo,Xie, Yongtao,Li, Yonghong,Li, Zhengming
supporting information, p. 3365 - 3369 (2017/07/07)
A series of sulfonylurea derivatives containing a 2,6-disubstituted aryl moiety were designed, synthesized and evaluated for their herbicidal activities. Most of these compounds showed excellent inhibitory rates against both monocotyledonous and dicotyledonous weeds, especially 10a, 10h and 10i. They exhibited equivalent or superior herbicidal efficiency than commercial chlorsulfuron at the dosage of 15?g/ha and the preliminary SAR was summarized. In order to illuminate the molecular mechanism of several potent compounds, their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors. 10i have a Kiapp of 11.5?nM, which is about 4 times as potent as chlorsulfuron (52.4?nM).
Gold supported on titania for specific monohydrogenation of dinitroaromatics in the liquid phase
Liu, Shuang-Shuang,Liu, Xiang,Yu, Lei,Liu, Yong-Mei,He, He-Yong,Cao, Yong
, p. 4162 - 4169 (2014/09/29)
Liquid-phase selective monohydrogenation of various substituted dinitroaromatics to the corresponding valuable nitroanilines was investigated on gold-based catalysts. Special attention was paid to the effect of Au particle size on this monoreduction reaction. Interestingly, TiO2 supported gold catalysts containing a relatively larger mean Au particle size (>5 nm) showed far superior chemoselectivity for specific mono-hydrogenation of dinitroaromatics, with the highest performance attainable for the catalyst bearing Au particles of ca. 7.5 nm. Results in the intermolecular competitive hydrogenation showed that the intrinsic higher accumulation rates of the desired nitroanilines associated with the catalyst possessing larger Au particles were responsible for the high chemoselectivity observed. the Partner Organisations 2014.
Convenient chlorination of some special aromatic compounds using N-chlorosuccinimide
Gan, Zongjie,Hu, Bin,Song, Qiao,Xu, Yungen
experimental part, p. 1074 - 1078 (2012/05/04)
Some chlorinated aromatic compounds, including indole, benzofuran, carbazole, pyridine and aniline derivatives, are difficult to obtain through convenient chlorination. We herein report their efficient synthesis through chlorination with N-chlorosuccinimide (NCS). Optimization of the reaction conditions, including the temperature and the choice of solvent, was also investigated. This approach, which is characterized by a facile procedure, comparatively high yields and environmentally friendly features, provides a straightforward and inexpensive route to several chlorinated aromatic compounds. Georg Thieme Verlag Stuttgart · New York.
Heteromeric double helix formation by cross-hybridization of chloro-and fluoro-substituted quinoline oligoamides
Gan, Quan,Li, Fei,Li, Guoping,Kauffmann, Brice,Xiang, Junfeng,Huc, Ivani,Jiang, Hua
supporting information; experimental part, p. 297 - 299 (2010/05/01)
Oligoamides of 8-chloroquinoline have been synthesized and shown to assemble into double helical dimers both in solution and in the solid state, and to undergo cross-hybridization with 8-fluoroquinoline oligoamide analogues; the handedness of these double
FUSED PYRIMIDINE DERIVATIVE AND USES THEREOF
-
Page/Page column 71, (2008/06/13)
A compound represented by the formula (I) wherein ring A is a 5-membered aromatic heterocycle optionally having substituent(s), R1 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), W is an oxygen atom or a sulfur atom, X1 and X2 may be the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s) or a heterocyclic group, or, X1 and X2 in combination optionally form an oxygen atom, a sulfur atom or =NR2, ring B is an aromatic ring optionally further having substituent(s), Y is a bond, C1-6 alkylene C2-6 alkenylene or C2-6 alkynylene, optionally having substituent(s), and Z is a group represented by formula: -SOnR3, or a group represented by formula: -COR4, or a salt thereof, is useful as a pharmaceutical agent having GnRH antagonistic action.
Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity
-
Page column 48, (2010/02/05)
A compound of formula (I) wherein: n is 1 or 2; R 1 is chloro, fluoro, bromo, methyl or methoxy; R 2 is as defined within; R 3 is as defined within; and R 4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed. STR1
Preparation and NMR analysis of 2,6-heterodifunctional halobenzenes as precursors for substituted biphenyls
Sienkowska, Monika,Benin, Vladimir,Kaszynski, Piotr
, p. 165 - 173 (2007/10/03)
Preparation and complete characterization of 16 2,6-disubstituted halobenzenes, including nine new compounds, from two common starting materials is described. Seven of the new compounds contain one or two propylthio groups, which have been introduced in two ways. Direct reaction of arenediazonium salts with 1-propanethiolate gives yields comparable to those obtained in a three-step method through sulfonyl chlorides. The 1H- and 13C NMR chemical shifts of 17 1,2,3-trisubstituted benzenes have been correlated with the predicted values and the observed trends explained using commonly available modeling packages.