39713-40-1

Basic information

• Product Name: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione
• Synonyms: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione;5H-Cyclohepta[b]pyridine-7,8-dihydro-5,9(6H)-dione;EOS-60494
• CAS NO: 39713-40-1
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18396
• Mol File: 39713-40-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 364.6±21.0 °C(Predicted)
• Appearance: /
• Density: 1.249
• PKA: 0.40±0.20(Predicted)
• CAS DataBase Reference: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(39713-40-1)
• EPA Substance Registry System: 7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione(39713-40-1)

Safety Data

• Hazardous Substances Data: 39713-40-1(Hazardous Substances Data)

Usage

Uses

7,8-dihydro-5H-cyclohepta[b]pyridine-5,9(6H)-dione is an organic intermediate, which can be prepared from dimethyl 2,3-pyridine dicarboxylate and dimethyl glutarate by two-step reaction.

Upstream product

• 39713-36-5 dimethyl 5,9-dihydroxy-7H-cyclohepta[b]pyridine-6,8-dicarboxylate 
• 605-38-9 dimethyl 2,3-pyridinedicarboxylate 

Downstream Products

• 1397526-07-6 (6R,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one 
• 1397525-83-5 (5S,6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-ol hydrochloride 
• 1190363-51-9 (5S,6S,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-yl methanesulfonate 
• 1190363-52-0 (6R,9R)-6-(2,3-difluorophenyl)-9-(triisopropylsilyloxy)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine 
• 1190363-49-5 (6R,9R)-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol 
• 1190363-03-1 BMS-846372 
• 1190363-46-2 (6S,9R)-6-(2,3-difluorophenyl)-9-((triisopropylsilyl)oxy)-6,7,8,9-tetrahydro-5Hcyclohepta[b]pyridin-5-one 

Relevant articles and documents

Efficient and scalable enantioselective synthesis of a CGRP antagonist

An enantioselective synthesis of the CGRP antagonist BMS-846372, amenable to large scale preparation, is presented. This new synthesis showcases a chemo- and enantioselective reduction of a cyclohepta[b]pyridine-5,9-dione as well as a Pd-catalyzed alpha-arylation reaction to form the key carbon-carbon bond and set the absolute and relative stereochemistry.