397290-30-1

Basic information

• Product Name: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole
• Synonyms: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole;Gue1654
• CAS NO: 397290-30-1
• Molecular Formula: C23H17N3OS3
• Molecular Weight: 447.59558
• Mol File: 397290-30-1.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble5mg/mL (clear solution; warmed)
• CAS DataBase Reference: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole(397290-30-1)
• EPA Substance Registry System: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole(397290-30-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 397290-30-1(Hazardous Substances Data)

Usage

Description

Gue1654 is a Gβγ-signaling-biased 5-OxoETE receptor antagonist. It inhibits neutrophil and eosinophil shape change and chemotaxis induced by 5-OxoETE (Item No. 34250) but not chemoattractant C5a or prostaglandin D2 (PGD2; ). Gue1654 inhibits 5-OxoETE-induced Gβγ-mediated inositol monophosphate (IP1) production in HEK293 cells transiently expressing the 5-OxoETE receptor, an effect that can be blocked by the Gβγ-inhibitor gallein, but has no effect on IP1 production induced by stimulation of endogenous Gαq-linked muscarinic receptors. In a bioluminescence resonance energy transfer (BRET) assay, Gue1654 reduces the 5-OxoETE-induced, but not basal, BRET fluorescence response, indicating disruption of the interaction between ligand-activated 5-OxoETE receptor and Gβγ.

Uses

Gue 1654 is a selective inhibitor of OXE-R Gβγ signaling.