3973-63-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Phenyl-delta-valerolactam is used as a key intermediate in the synthesis of pharmaceuticals for its unique structure and reactivity, which can contribute to the development of new drugs with enhanced properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Phenyl-delta-valerolactam is utilized as a building block for the creation of novel agrochemicals, potentially leading to more effective and environmentally friendly products.
Used in Polymer Industry:
4-Phenyl-delta-valerolactam is employed as a monomer in the production of advanced polymers, where its unique structure can improve the material's properties, such as strength, flexibility, and durability.
Used as a Catalyst in Organic Reactions:
Due to its reactivity, 4-Phenyl-delta-valerolactam is used as a catalyst in various organic reactions, facilitating the synthesis of complex organic compounds with improved efficiency and selectivity.
Used in Organic Synthesis Research:
4-Phenyl-delta-valerolactam serves as a valuable building block for the synthesis of a wide range of organic compounds, making it an essential component in the development of new chemical entities and materials for various applications.

Upstream product

• 105909-96-4 2-oxo-5-phenyl-piperidine-3-carboxylic acid 
• 64145-51-3 3-phenylcyclopentanone 
• 107522-01-0 2-oxo-5-phenyl-piperidine-3-carboxylic acid ethyl ester 
• 61782-31-8 2-phenylglutar-1-amide 
• 88611-73-8 methyl 4-cyano-4-phenylbutanoate 

Downstream Products

• 99854-36-1 3,3-dichloro-5-phenyl-piperidin-2-one 
• 99853-39-1 3,3-dibromo-5-phenyl-piperidin-2-one 
• 76696-89-4 Ethoxy-2 phenyl-5 tetrahydro-3,4,5,6 pyridine 
• 3973-62-4 3-phenylpiperidine 
• 1076190-79-8 1-(1H-imidazol-1-ylmethyl)-5-phenylpiperidin-2-one 
• 1076190-73-2 1-(chloromethyl)-5-phenylpiperidin-2-one 
• 1076190-63-0 1-(hydroxymethyl)-5-phenylpiperidin-2-one 
• 706792-90-7 1,1-dimethylethyl 3-bromo-5-(2-oxo-5-phenyl-1-piperidinyl)benzoate 
• 96314-26-0 (trans)-4-Phenyl-S-proline 
• 99859-73-1 3-chloro-5-phenyl-piperidin-2-one 
• 76696-94-1 3-(3-Oxo-6-phenyl-2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridin-2-yl)-propionic acid ethyl ester 
• 82256-89-1 6-Phenyl-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine 
• 82256-78-8 3,6-Diphenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine 
• 82256-68-6 6-Phenyl-2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Synthesis of lactams by regioselective reduction of cyclic dicarboximides

Lactams can be obtained by the monothionation of imides with Lawesson's reagent followed by the desulfurization of resulted monothioimides with Raney nickel.

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ-Lactams

Metal-catalyzed hydrogenation is an effective method to transform readily available arenes into saturated motifs, however, current hydrogenation strategies are limited to the formation of C?H and N?H bonds. The stepwise addition of hydrogen yields reactive unsaturated intermediates that are rapidly reduced. In contrast, the interruption of complete hydrogenation by further functionalization of unsaturated intermediates offers great potential for increasing chemical complexity in a single reaction step. Overcoming the tenet of full reduction in arene hydrogenation has been seldom demonstrated. In this work we report the synthesis of sought-after, enantioenriched δ-lactams from oxazolidinone-substituted pyridines and water by an interrupted hydrogenation mechanism.

Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

A direct catalytic method is described for the α,β-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods. Lactams with various ring sizes and substituents at different positions all reacted smoothly. The synthetic utility of this method is demonstrated in a concise synthesis of Rolipram. In addition, linear amides also prove to be competent substrates, and the phthaloyl-protected product serves as a convenient precursor to access various conjugated carboxylic acid derivatives. Strong bases are avoided in this desaturation approach, and the key is to merge soft enolization with a Pd-catalyzed oxidation process.