3973-63-5

Basic information

• Product Name: 4-PHENYL-DELTA-VALEROLACTAM
• Synonyms: 4-PHENYL-DELTA-VALEROLACTAM;5-Phenylpiperidin-2-one;5-phenyl-2-piperidinone;5-phenyl-2-piperidone
• CAS NO: 3973-63-5
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3973-63-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PHENYL-DELTA-VALEROLACTAM(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-DELTA-VALEROLACTAM(3973-63-5)
• EPA Substance Registry System: 4-PHENYL-DELTA-VALEROLACTAM(3973-63-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3973-63-5(Hazardous Substances Data)

Usage

General Description

4-Phenyl-delta-valerolactam is a chemical compound that consists of a five-membered lactam ring with a phenyl group and a valeric acid side chain. It is a derivative of valerolactam, which is commonly used in the production of nylon. The addition of a phenyl group to the valerolactam molecule can alter its properties and potentially enhance its use in various industrial applications such as in the synthesis of pharmaceuticals, agrochemicals, and polymers. 4-PHENYL-DELTA-VALEROLACTAM has been studied for its potential use as a catalyst in organic reactions and as a building block for the synthesis of various organic compounds due to its unique structure and reactivity. Its properties and potential applications make it an interesting compound for further research and development in the field of organic chemistry.

Upstream product

• 88611-73-8 methyl 4-cyano-4-phenylbutanoate 
• 64145-51-3 3-phenylcyclopentanone 
• 107522-01-0 2-oxo-5-phenyl-piperidine-3-carboxylic acid ethyl ester 
• 61782-31-8 2-phenylglutar-1-amide 
• 105909-96-4 2-oxo-5-phenyl-piperidine-3-carboxylic acid 

Downstream Products

• 99854-36-1 3,3-dichloro-5-phenyl-piperidin-2-one 
• 99853-39-1 3,3-dibromo-5-phenyl-piperidin-2-one 
• 76696-89-4 Ethoxy-2 phenyl-5 tetrahydro-3,4,5,6 pyridine 
• 3973-62-4 3-phenylpiperidine 
• 1076190-63-0 1-(hydroxymethyl)-5-phenylpiperidin-2-one 
• 1076190-79-8 1-(1H-imidazol-1-ylmethyl)-5-phenylpiperidin-2-one 
• 1076190-73-2 1-(chloromethyl)-5-phenylpiperidin-2-one 
• 706792-90-7 1,1-dimethylethyl 3-bromo-5-(2-oxo-5-phenyl-1-piperidinyl)benzoate 
• 96314-26-0 (trans)-4-Phenyl-S-proline 
• 99859-73-1 3-chloro-5-phenyl-piperidin-2-one 
• 76696-94-1 3-(3-Oxo-6-phenyl-2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridin-2-yl)-propionic acid ethyl ester 
• 82256-89-1 6-Phenyl-3-pyridin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine 
• 82256-78-8 3,6-Diphenyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine 
• 82256-68-6 6-Phenyl-2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine 

Relevant articles and documents

Synthesis of lactams by regioselective reduction of cyclic dicarboximides

Lactams can be obtained by the monothionation of imides with Lawesson's reagent followed by the desulfurization of resulted monothioimides with Raney nickel.

Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

A direct catalytic method is described for the α,β-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods. Lactams with various ring sizes and substituents at different positions all reacted smoothly. The synthetic utility of this method is demonstrated in a concise synthesis of Rolipram. In addition, linear amides also prove to be competent substrates, and the phthaloyl-protected product serves as a convenient precursor to access various conjugated carboxylic acid derivatives. Strong bases are avoided in this desaturation approach, and the key is to merge soft enolization with a Pd-catalyzed oxidation process.