397301-41-6Relevant articles and documents
Synthetic study on the unique dimeric arylpiperazine: Access to the minor contaminant of aripiprazole
Torisawa, Yasuhiro,Shinhama, Koichi,Nishi, Takao,Minamikawa, Jun-ichi
, p. 65 - 68 (2007/10/03)
The dimeric derivative of Aripiprazole was synthesized via the two notable synthetic technologies as a key step: (1) efficient aldehyde bis-arylation by Bi(OTf)3 and (2) facile Wynberg amination at room temperature. The synthesis has established the structural identity with the minor contaminant sometimes present in Aripiprazole.
NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction.
Torisawa,Nishi,Minamikawa
, p. 2787 - 2789 (2007/10/03)
Enhanced reactivity of NaBH4 was observed as a solution in N-methylpyrrolidone (NMP). Thus, a simple protocol for debromination of alkyl bromide and sulfonate is devised with NMP as a key solvent. Also described is a new mixed borohydride system, NaBH4-LiOTf-NMP, which works as an alternative to NaBH3CN for the SN2 type displacement. No reports have ever revealed usefulness of NMP in borohydride reduction.