397301-41-6

Usage

Uses

Used in Pharmaceutical Industry:
1,1'-Ethylidenebis[2,3-dichloro-4-methoxy-benzene is used as an intermediate in the preparation of ethylidenebisaripiprazole for its role in the development of medications targeting central nervous system disorders. Its chemical structure allows for the creation of compounds with potential therapeutic effects on conditions such as schizophrenia and bipolar disorder.
As an intermediate, 1,1'-Ethylidenebis[2,3-dichloro-4-methoxy-benzene contributes to the synthesis of ethylidenebisaripiprazole, which is a drug candidate with potential applications in treating psychiatric disorders. 1,1'-Ethylidenebis[2,3-dichloro-4-Methoxy-benzene's chemical properties make it a valuable component in the development of new medications aimed at improving the quality of life for patients suffering from these conditions.

Upstream product

• 397301-38-1 C₁₆H₁₃BrCl₄O₂ 

Downstream Products

• 519138-47-7 C₂₄H₃₀Cl₄N₄ 

Relevant academic research and scientific papers

Synthetic study on the unique dimeric arylpiperazine: Access to the minor contaminant of aripiprazole

The dimeric derivative of Aripiprazole was synthesized via the two notable synthetic technologies as a key step: (1) efficient aldehyde bis-arylation by Bi(OTf)3 and (2) facile Wynberg amination at room temperature. The synthesis has established the structural identity with the minor contaminant sometimes present in Aripiprazole.

Some aspects of NaBH4 reduction in NMP

In our solvent optimization study of NaBH4 reduction, NMP was found to enhance the reactivity. A chemoselective debromination of the bromide and sulfonates can be attained in the new borohydride reagent system: NaBH4-LiOTf-NMP. This mixed system worked as an alternative to NaBH3CN and Bu3SnH for the SN2 type displacement of alkylbromide and sulfonate. Also mentioned is an expedient reduction of an azide group into amine by NaBH4 in NMP without any additive, which offers a convenient protocol for the direct transformation of halides into amines via azide in one flask. Some examples of other reductions were also presented.

NaBH4 in N-methylpyrrolidone: a safe alternative for hydride displacement reaction.

Enhanced reactivity of NaBH4 was observed as a solution in N-methylpyrrolidone (NMP). Thus, a simple protocol for debromination of alkyl bromide and sulfonate is devised with NMP as a key solvent. Also described is a new mixed borohydride system, NaBH4-LiOTf-NMP, which works as an alternative to NaBH3CN for the SN2 type displacement. No reports have ever revealed usefulness of NMP in borohydride reduction.