39743-22-1

Upstream product

• 3179-63-3 3-Dimethylamino-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 58-40-2 promazine 
• 58625-59-5 2-n-propyl-3-(3,5-dimethyl-4-γ-dimethylaminopropoxy-benzoyl)-benzo[b]thiophene hydrochloride 
• 1232234-01-3 4-(3-chloro-phenyl)-2-[6-(3-dimethylamino-propoxy)-benzoimidazol-1-yl]-thiazole-5-carboxylic acid amide 
• 1259938-65-2 C₂₉H₃₀F₃N₃O₅S 
• 5205-93-6 2-methyl-acrylic acid 3-dimethylamino-propyl amide 

Relevant academic research and scientific papers

triAZOLOtriAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS

The present invention provides triazolotriazine derivatives of formula (1) as A2A receptor antagonists. Compounds of formula (1) and pharmaceutical compositions including the compounds can be used for the treatment of disorders related to A2A receptor hyperfunctioning, such as certain types cancers. Compounds of formula (1) and methods of preparing the compounds are disclosed in the invention.

Preparation method of N-dimethylaminopropyl(meth)acrylamide

The invention discloses a preparation method of N-dimethylaminopropyl(meth)acrylamide. The preparation method comprises the following steps: firstly, carrying out alcohol derivatization on 3-dimethylamino-1-propanol; reacting the derivatization product with (meth)acrylamide in the presence of an organic solvent and an alkali to obtain the N-dimethylaminopropyl(meth)acrylamide. Compared with a conventional preparation method adopted in the market, the preparation method disclosed by the invention has the advantages that the reaction conditions are mild, the operation is simple and convenient, the control is easy, the preparation cost is relatively low, and the commercial value is relatively high.

Thiazolyl-Benzimidazoles

The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.