39757-69-2Relevant academic research and scientific papers
Design, synthesis and evaluation of a novel cyclohexanamine class of neuropeptide Y Y1 receptor antagonists
Cho, Kaimei,Ando, Makoto,Kobayashi, Kensuke,Miyazoe, Hiroshi,Tsujino, Toshiaki,Ito, Sayaka,Suzuki, Tomoki,Tanaka, Takeshi,Tokita, Shigeru,Sato, Nagaaki
scheme or table, p. 4781 - 4785 (2010/07/06)
A novel series of cyclohexanamine derivatives was designed and synthesized as potent and selective human neuropeptide Y Y1 receptor antagonists. Modification of high-throughput screening hit compound 1 resulted in the identification of compound 3i, which displays potent Y1 activity and good selectivity towards hERG K+ channel and serotonin transporter.
