39758-39-9Relevant academic research and scientific papers
Selective Alkenylation and Hydroalkenylation of Enol Phosphates through Direct C-H Functionalization
Hu, Xu-Hong,Yang, Xiao-Fei,Loh, Teck-Peng
, p. 15535 - 15539 (2015)
An efficient and selective Rh-catalyzed direct C-H functionalization reaction of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and leads to the formation of various valuable alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The versatility and utility of the coupling products were demonstrated through further transformations into synthetically useful building blocks. P points the way: A direct C-H functionalization of enol phosphates was developed. The method is applicable to a variety of coupling partners, including activated alkenes, alkynes, and allenes, and it leads to the formation of alkenylated and hydroalkenylated enol phosphates through the action of the phosphate directing group. The utility of the coupling products are demonstrated by further transformations into synthetically useful building blocks.
A Stereoselective Reductive Hosomi-Sakurai Reaction
Bauer, Adriano,Maulide, Nuno
supporting information, p. 1461 - 1464 (2018/03/09)
A novel reductive variant of the classical Hosomi-Sakurai reaction is reported. This transformation hinges on a redox-neutral, stereoselective internal reduction event under mild conditions. This operationally simple reaction relies on readily available starting materials and leads to useful products in diastereoselectivities of up to 7:1. The versatility of this new method is demonstrated through the stereoselective one-step synthesis of an AChE inhibitor.
Trifluoromethylation of allylsilanes under copper catalysis
Mizuta, Satoshi,Galicia-Lopez, Oscar,Engle, Keary M.,Verhoog, Stefan,Wheelhouse, Katherine,Rassias, Gerasimos,Gouverneur, Veronique
supporting information; experimental part, p. 8583 - 8587 (2012/08/14)
Branched allylic CF3 products are accessible by copper-catalyzed trifluoromethylation of allylsilanes with the Togni reagent I. The silyl group is critical to control the outcome of this reaction because in its absence, a product of addition be
