39763-72-9Relevant articles and documents
Histone acetyltransferase P300 small molecule inhibitor and medicinal composition and application thereof
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Paragraph 0099-0103, (2020/03/17)
The compound capable of inhibiting histone acetyltransferase, has a significant inhibition effect p300 in inhibiting the activity, of the histone acetyltransferase, or a pharmaceutically acceptable salt (I) of; has a significant inhibitory effect on tumor cells such as the primary, representative small molecule inhibitor p300 to prostate cancer cells, malignant blood tumor cells p300 breast cancer cells, and has an effect of inhibiting the toxicity C646, of the compound by overcoming the defects, of the original, small molecule inhibitor, existing in the present invention. C646 p300. The compounds of the formula C646; are shown in, Table (I). The invention belongs to, the field of pharmaceutical chemistry.