3978-17-4Relevant academic research and scientific papers
A novel route to 2-(dialkylaminomethyl)benzo[b]furans via a microwave-enhanced, solventless Mannich condensation-cyclization on cuprous iodide doped alumina
Kabalka, George W,Wang, Lei,Pagni, Richard M
, p. 6049 - 6051 (2001)
A microwave-enhanced, solventless Mannich condensation-cyclization sequence involving the reaction of o-ethynylphenol with secondary amines and para-formaldehyde on cuprous iodide doped alumina in the absence of solvents has been developed. The procedure generates 2-(dialkylaminomethyl)benzo[b]furans in good yields.
A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina
Kabalka, George W.,Zhou, Li-Li,Wang, Lei,Pagni, Richard M.
, p. 857 - 867 (2007/10/03)
A microwave-enhanced, solventless Mannich condensation of terminal alkynes and secondary amines with para-formaldehyde on cuprous iodide doped alumina has been developed. β-Aminoalkynes are generated in good yields. The reaction can be extended to include a cyclization, which affords 2-substituted benzo[b]furans. The chemoselectivity of the reaction indicates that terminal alkynes are much more reactive than enolizable ketones under the reaction conditions.
