397870-41-6

Upstream product

• 338387-13-6 (5R,6R)-6-Acetyl-6-(3,3-diethoxy-propyl)-5-isopropenyl-2-methyl-cyclohex-2-enone 
• 338387-12-5 (S)-6-Acetyl-5-isopropenyl-2-methyl-cyclohex-2-enone 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 338387-14-7 3-((1R,6R)-1-Acetyl-6-isopropenyl-3-methyl-2-oxo-cyclohex-3-enyl)-propionaldehyde 

Downstream Products

• 397870-42-7 (5R,6R)-6-acetyl-6-((E)-5-(tert-butyldimethylsilyloxy)-4-methylhexa-3,5-dienyl)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-enone 

Relevant academic research and scientific papers

Stereoselective synthesis of polyoxygenated atisane-type diterpenoids

A new stereoselective approach to polyoxygenated atisane-type diterpenes starting from (S)-(+)-carvone is described. The key steps involve an intramolecular Diels-Alder reaction, an unusual intramolecular diazo ketone cyclopropanation of an unsaturated ketone, and a regioselective endocyclic cleavage of a cyclopropyl carbinyl radical as key synthetic steps. The synthesis of the bioactive polyoxygenated atisanes atis-16(17)-en-3,14-dione (2) and 3R-hydroxy-atis-16(17)-en-2,14-dione (3) following this approach is presented.