397883-75-9

Basic information

• Product Name: 3-Pyrrolidinemethanol, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (3R,4R)-
• CAS NO: 397883-75-9
• Molecular Formula: C20H25NO2
• Molecular Weight: 311.424
• Mol File: 397883-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Pyrrolidinemethanol, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (3R,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinemethanol, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (3R,4R)-(397883-75-9)
• EPA Substance Registry System: 3-Pyrrolidinemethanol, 1-[(1S)-1-phenylethyl]-4-(phenylmethoxy)-, (3R,4R)-(397883-75-9)

Safety Data

• Hazardous Substances Data: 397883-75-9(Hazardous Substances Data)

Upstream product

• 320385-10-2 (E)-3-benzyloxypropenoyl-(2'S)-bornane-10,2-sultam 
• 143140-08-3 N-(S)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine 

Downstream Products

• 267421-93-2 (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine 

Relevant articles and documents

Synthesis of enantiomerically pure 4-substituted pyrrolidin-3-ols via asymmetric 1,3-dipolar cycloaddition

Asymmetric 1,3-dipolar cycloadditions of chiral azomethine ylides to 3-benzyloxy-substituted alkenoylcamphorsultams are described. trans-3,4-Disubstituted pyrrolidines containing a protected hydroxyl group at C(4) of the pyrrolidine ring are obtained in high diastereomeric ratios. Such compounds can serve as chiral building blocks for the syntheses of enantiopure bioactive pyrrolidines. This is exemplified by a short synthetic route to a known glycosidase inhibitor, (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol and its enantiomer.