397886-68-9

Upstream product

• 397886-58-7 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-enoic acid methyl ester 
• 397886-59-8 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-en-1-ol 
• 397886-57-6 (E)-(5R,6R)-7-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-5-methyl-hept-2-enoic acid methyl ester 
• 112031-78-4 3,4-dideoxy-3-C-methyl-5-O-tert-butyldiphenylsilyl-D-erythro-pentitol 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 397886-67-8 Acetic acid (E)-(5R,6R)-7-hydroxy-6-(4-methoxy-benzyloxy)-5-methyl-hept-2-enyl ester 

Downstream Products

• 397886-61-2 Acetic acid (E)-(5R,6R)-8,8-dibromo-6-(4-methoxy-benzyloxy)-5-methyl-octa-2,7-dienyl ester 
• 397886-62-3 2,2-Dimethyl-propionic acid 2-[(2S,4R,6S)-6-[(2E,9E)-(6R,7R)-11-hydroxy-6-(4-methoxy-benzyloxy)-7-methyl-undeca-2,9-dien-4-ynyl]-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-ethyl ester 
• 397886-47-4 (E)-(5R,6R)-6-(4-Methoxy-benzyloxy)-5-methyl-oct-2-en-7-yn-1-ol 

Relevant academic research and scientific papers

Synthetic studies aimed at (-)-cochleamycin A. Evaluation of late-stage macrocyclization alternatives

An efficient route to the fully functionalized ABC ring systems of the unnatural enantiomer of cochleamycin A was developed. L-(-)-Malic and L-(-)-ascorbic acids served well as starting materials for the two building blocks used to construct an (E,Z,E)-1,

Studies aimed at the total synthesis of the antitumor antibiotic cochleamycin A. An enantioselective biosynthesis-based pathway to the AB bicyclic core

Chemical equation presented A convergent, highly enantioselective synthesis of the fully functionalized AB sector of cochleamycin A is described. A pair of building blocks, crafted from L-malic and L-ascorbic acids, are conjoined in a manner that gives ri