39799-67-2Relevant academic research and scientific papers
JOINT EFFECT OF STRUCTURE OF REAGENTS AND TEMPERATURE ON REACTIVITY OF AROYL BROMIDE-PRIMARY ARYLAMINE SYSTEMS IN BENZENE. CROSSED CORRELATION
Shpan'ko, I. V.,Goncharov, A. N.,Likhomanenko, E. E.
, p. 522 - 530 (2007/10/02)
The kinetics of the reactions of aroyl bromides with primary arylamines in benzene were studied at 10, 25, 40, and 55 deg C.The effects of factors (temperature, the structure of the aroyl bromides and primary arylamines) varied separately and in pairs and also the joint effect of the three factors on the process rate were assessed quantitatively.The joint effect of the structure of the primary arylamines and the temperature on the reactivity of the system is nonadditive, and the effect of the structure of the aroyl bromides and temperature is additive.The influence of the varied parameters on the nature of the translation states in the reactions is discussed.
Synthesis of a Distamycin Analogue: Tris(m-benzamido) Compound
Rajagopalan, Malini,Rao, K. Ekambareswara,Ayyer, Jayalekshmy,Sasisekharan, V.
, p. 1021 - 1024 (2007/10/02)
In order to understand the role of curvature of ligand in conformational and chemical specificity of DNA-drug interactions a number of compounds have been synthesised.The synthetic strategy for one of the compounds in the series, tris(m-benzamido) compound, an analogue of Dst, which is essentially based on the route used by Bialer et al. , 2239> for the synthesis of Dst with some modifications wherever necessary is reported.
JOINT EFFECT OF THE STRUCTURE OF THE REAGENTS AND THE POLARITY OF THE MEDIUM ON THE RATE OF REACTIONS OF AROYL CHLORIDES WITH PRIMARY ARYLAMINES. CROSSED CORRELATION
Shpan'ko, I. V.,Likhomanenko, E. E.,Litvinenko, L. M.,Goncharov, A. N.
, p. 1390 - 1397 (2007/10/02)
The kinetics of the reactions of aroyl chlorides with primary arylamines in volume mixtures of chlorobenzene with nitrobenzene were studied with crossed variation in the structures of the reagents.The effect of various factors (the structure of the primary arylamines, the structure of the aroyl chlorides, the polarity of the medium), varied separately and in pairs, and also the joint effect of the three factors on the process rate were assessed.It was found that the structure of the reagents and the polarity of the medium have a nonadditive type of mutual effect on the reactivity of the aroyl chloride-primary arylamine system.The influence of the varied factors on the nature of the transition states in the reactions is discussed.
Conformational Behaviour of Medium-sized Rings. Part 15. 1,9,17-Triazametacyclophane-2,10,18-trione Derivatives
Elhadi, Farouk Eltayeb,Ollis, W. David,Stoddart, J. Fraser
, p. 1727 - 1732 (2007/10/02)
The stepwise synthesis of 1,9-dimethyl-1,9,17-triazametacyclophane-2,10,18-trione (1) from methyl m-aminobenzoate and m-nitrobenzoyl chloride is reported.The temperature dependences (i) of the 1H-decoupled 13C n.m.r. spectrum of the 1,9,17-trimethyl derivative (2) and (ii) of the 1H n.m.r. spectrum of the 1,9-dimethyl-17-benzyl derivative (3) are interpreted in terms of equilibration between diastereoisomeric crown and saddle conformations in solution.The 1,9-dimethyl derivative (1) is believed to exist predominantly in the saddle conformation in solution.
Synthesis and conformational behaviour of 1,9,17-triaza[2.2.2]metacyclophane-2, 10, 18-trione derivatives
Elhadi, Farouk Eltayeb,David Ollis,Fraser Stoddart,Williams, David J.,Woode, Kwamena A.
, p. 4215 - 4218 (2007/10/02)
The 1,9,17-triaza[2.2.2]metacyclophane-2, 10, 18-trione derivatives (1) - (3) have been synthesised. X-Ray crystallography shows that the 1,9,17-trimethyl derivative (3) adopts a Crown conformation (11) in the solid state. Dynamic n.m.r. spectroscopy indi
