398-82-3

Upstream product

• 401-27-4 (+/-)-(2,4-dichloro-phenoxy)-fluoro-acetic acid ethyl ester 
• 343220-68-8 C₁₁H₁₃Cl₂FO₃Si 
• 94-75-7 2,4-Dichlorophenoxyacetic acid 
• 109-69-3 n-Butyl chloride 
• 359-25-1 bromo-fluoroacetic acid 
• 120-83-2 2,4-dichlorophenol 
• 57-24-9 strychnidin-10-one 
• 344406-44-6 1-(2,2-Bis-trimethylsilanyloxy-vinyloxy)-2,4-dichloro-benzene 

Downstream Products

• 772-23-6 2,4-di-chloro-1-(difluoromethoxy)benzene 

Relevant academic research and scientific papers

Herbicidal and fungistatic properties of fluorine analogs of phenoxyacetic herbicides

Aryloxy fluoroacetic acids 3a-3h – fluorine analogs of phenoxyacetic herbicides 2,4-D, MCPA, 2,4,5-T, and 4-CPA were efficiently synthesized in 29–88% yield, using appropriate phenols and either bromodifluoro- or bromofluoroacetic acid in the presence of sodium hydride as a base and in either dioxane or THF as solvents. Fluorine derivatives of 2,4-D (3a, 3b) show herbicidal activity against three weed species. Parent herbicides 2,4-D, MCPA, 2,4,5-T, 4-CPA, monofluorine derivatives of MCPA (3d) and 2,4,5-T (3f) show fungistatic activity against phytopatogenic fungi species Phytophtora cactorum.

Xenon Difluoride Mediated Fluorodecarboxylations for the Syntheses of Di- and Trifluoromethoxyarenes

XeF2 is demonstrated to be a more proficient fluorine-transfer reagent than either NFSI or Selectfluor in fluorodecarboxylations of both mono- and difluoroaryloxy acetic acid derivatives. This method efficiently converts a wide range of neutral and electron-poor substrates to afford the desired di- and trifluoromethyl aryl ethers in good to excellent yields. The purifications are facile, and the reaction times are less than 5 min, which makes these fluorodecarboxylations promising for future PET-imaging applications.

Synthesis of α-fluorocarbonyl compounds

Process for preparing an organic compound of the formula R2 R2 CFC(O)R3, which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and STR1 R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF2 ; R1 is hydrocarbyl of 1-6 carbon atoms; each R2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; R3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R1)3, OH, NH2, alkoxy of 1-6 carbon atoms, aryloxy, NHR1 and NR12 wherein R1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; R3 and one R2 taken together is a diradical which with the C=C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R2 R2 CFC(O)R3.