398148-62-4Relevant academic research and scientific papers
Attrition-enhanced deracemization of an amino acid derivative that forms an epitaxial racemic conglomerate
Kaptein, Bernard,Noorduin, Wim L.,Meekes, Hugo,Van Enckevort, Willem J. P.,Kellogg, Richard M.,Vlieg, Elias
, p. 7226 - 7229 (2008)
(Chemical Equation Presented) Just bead it! Despite the complication of enantiomeric epitaxial behavior, a derivative of phenylalanine was completely resolved (see picture). Racemization takes place by abrasively grinding crystals of the compound in a saturated solution. By studying the influence of different crystal sizes, it was found that Ostwald ripening plays an important role in this process. DBU = 1,8-diazabicyclo-[5.4.0]undec-7-ene.
Amine-Directed Palladium-Catalyzed C?H Halogenation of Phenylalanine Derivatives
Ville, Alexia,Annibaletto, Julien,Coufourier, Sébastien,Hoarau, Christophe,Tamion, Rodolphe,Journot, Guillaume,Schneider, Cédric,Brière, Jean-Fran?ois
supporting information, p. 13961 - 13965 (2021/09/14)
An efficient primary-amine-directed, palladium-catalyzed C?H halogenation (X=I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suitable conditions employing trifluoroacetic acid as additive. The extension of this original native functionality-directed ortho-selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.
