39828-35-8

Basic information

• Product Name: 2,4-DIMETHOXYBENZOYL CHLORIDE
• Synonyms: 2,4-DIMETHOXYBENZOYL CHLORIDE;2,4-DIMETHOXYBENZOYL CHLORIDE, TECH.;Benzoyl chloride, 2,4-dimethoxy- (9CI);2,4-Dimethoxybenzoyl chloride, 97+%;2,4-Dimethoxybenzoyl chloride,98%;2,4-Dimethoxybenzoyl chloride technical grade
• CAS NO: 39828-35-8
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• Product Categories: ACIDHALIDE;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 39828-35-8.mol
• Article Data: 69

Chemical Properties

• Melting Point: 58-60 °C(lit.)
• Boiling Point: 306.7 ºC at 760 mmHg
• Flash Point: 134.1 ºC
• Appearance: beige to light brown powder / beige to light brown powder
• Density: 1.224
• Vapor Pressure: 0.000757mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2,4-DIMETHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYBENZOYL CHLORIDE(39828-35-8)
• EPA Substance Registry System: 2,4-DIMETHOXYBENZOYL CHLORIDE(39828-35-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 39828-35-8(Hazardous Substances Data)

Usage

Chemical Properties

beige to light brown powder

Uses

Different sources of media describe the Uses of 39828-35-8 differently. You can refer to the following data:
1. Growth regulator and fruit thinner for plums and prunes.
2. 2,4-Dimethoxybenzoyl chloride may be used as starting reagent in the synthesis of coumestrol. It may be used in the synthesis of chromenoflavone, cycloartocarpesin trimethyl ether.

General Description

2,4-Dimethoxybenzoyl chloride is a benzoyl chloride derivative.

InChI:InChI=1/C9H9ClO3/c1-12-6-3-4-7(9(10)11)8(5-6)13-2/h3-5H,1-2H3

Upstream product

• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 91-52-1 2,4 dimethoxybenzoic acid 

Downstream Products

• 101094-23-9 2,4,6-trihydroxy-2',4'-dimethoxy-benzophenone 
• 76246-93-0 1-(2,4-dimethoxyphenyl)-2-phenylethanone 
• 4038-15-7 2,4,4'-trimethoxybenzophenone 
• 131-54-4 bis(2-hydroxy-4-methoxyphenyl)-methanone 
• 3555-85-9 2,2',4,4'-tetramethoxybenzophenone 
• 69818-99-1 2,4-dimethoxy-N-(5-nitro-thiazol-2-yl)-benzamide 
• 63484-16-2 4-[2-(2,4-Dimethoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl 
• 54133-43-6 2-(2,4-dimethoxybenzoyl)-3,5,5-trimethylcyclohex-2-enone 
• 65612-80-8 1,3-dioxo-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)propane 
• 64957-84-2 4,5-dihydro-2-(2',4'-dimethoxyphenyl)-4,4-dimethyloxazole 
• 122892-42-6 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-2,4-dimethoxy-benzamide 
• 131073-23-9 2-(2,4-dimethoxyphenyl)oxazolo<4,5-c>pyridine hydrochloride 
• 96617-37-7 N-(2-Hydroxy-1,1-dimethyl-ethyl)-2,4-dimethoxy-benzamide 
• 67836-51-5 2-(2,4-Dimethoxy-benzoylamino)-benzoic acid methyl ester 

Relevant articles and documents

Palladium-catalyzed C–P bond activation of aroyl phosphine oxides without the adjacent “anchoring atom”

A novel palladium-catalyzed decarbonylation of aroyl phosphine oxides to prepare phosphine oxides from carboxylic acids is developed. Without the adjacent “anchoring atom”, the challenging C–P bond activation is achieved in high selectivity. The disclosure of this reaction provides a new example of C–P bond activation and helps to extend the understanding of the property of C–P bond.

Total Synthesis of Mulberry Diels-Alder-Type Adducts Kuwanons G and H

Mulberry Diels-Alder-type adducts (MDAAs) are a group of rare natural polyphenols biosynthetically derived from [4 + 2]-cycloaddition of chalcones and dehydroprenylphenols. In this study, kuwanons G (1) and H (2), two bioactive MDAAs with unique dehydroprenylflavonoid dienes, were totally synthesized for the first time in a biomimetic manner. The key features of the convergent route include the use of the Baker-Venkataraman rearrangement, alkylation of β-diketone, intramolecular cyclization, and Suzuki-Miyaura coupling to achieve the subunit diene.

Computational discovery, structural optimization and biological evaluation of novel inhibitors targeting transient receptor potential vanilloid type 3 (TRPV3)

Transient receptor potential vanilloid type 3 (TRPV3) is a Ca2+ permeable nonselective cation channel and expressed abundantly in skin keratinocytes. TRPV3 emerges as an attractive target for treatment of pruritic, inflammatory, pain and skin-related diseases. However, only a few reports of TRPV3 inhibitors exist at present besides some patents. Therefore, TRPV3 research has always been fraught with challenges. Through a combination of virtual screening and biological evaluation, compound P1 (10 μM) was identified as a top hit with 34.5% inhibitory effect on 2-APB (1 mM)-evoked currents of mTRPV3-WT. Further structural optimization provided the inhibitor PC5 with the best activity (IC50 = 2.63 ± 0.28 μM), and point mutation assays indicated that amino acids V629 and F633 are crucial for the binding of PC5 and TRPV3. In summary, these newly discovered inhibitors could serve as promising lead compounds for the development of TRPV3 inhibitors in the future.