398489-28-6Relevant academic research and scientific papers
NITROGEN HETEROCYCLIC COMPOUNDS AND METHODS OF USE
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Paragraph 1808; 1909; 2070, (2021/06/26)
The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds as inhibitors of receptor tyrosine kinases, in particular oncogenic mutants of ErbB-receptors e.g. in the treatment of cancer.
Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis
Didier, Dorian,Joseph, Emanuel,Ni?l, Benedikt,Reiners, Felix
supporting information, p. 8533 - 8537 (2020/11/18)
Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the sy
SUBSTITUTED DIHYDROPYRAZOLO PYRAZINE CARBOXAMIDE DERIVATIVES
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Page/Page column 83, (2020/01/10)
The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions
Baumann, Andreas N.,Reiners, Felix,Juli, Thomas,Didier, Dorian
supporting information, p. 6736 - 6740 (2018/11/02)
By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.
Regiodivergent Stereoselective Access to Fused Alkylideneazetidines
Music, Arif,Baumann, Andreas N.,Eisold, Michael,Didier, Dorian
, p. 783 - 792 (2018/01/28)
Following recent advances in the generalization and simplification of 2H-azetine synthesis, a regiodivergent approach to fused 2- and 3-alkylideneazetines was designed via the intermediate formation of unprecedented vinylazetine structures. Concise sequen
Methods for the Synthesis of Substituted Azetines
Baumann, Andreas N.,Eisold, Michael,Music, Arif,Haas, Geoffrey,Kiw, Yu Min,Didier, Dorian
supporting information, p. 5681 - 5684 (2017/10/25)
Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from c
