39868-89-8

Upstream product

• 103-82-2 phenylacetic acid 
• 908093-98-1 diazodiphenylmethane 
• 91-01-0 1,1-Diphenylmethanol 
• 101-81-5 Diphenylmethane 

Downstream Products

• 1011458-35-7 benzhydryl 2-diazo-2-phenylacetate 
• 880348-55-0 2-phenyl-acrylic Acid Benzhydryl Ester 

Relevant academic research and scientific papers

Iron(III)-catalyzed direct synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine

A highly efficient method has been developed for the synthesis of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine. Various carboxylic acids readily reacted with 2-diphenylmethoxypyridine in the presence of FeCl3 as a catalyst to provide the desired DPM esters with high yields. The procedure is facile and enables effective synthesis of a variety of esters for the protection of carboxylic acids.

Sulfonated nanohydroxyapatite functionalized with 2-aminoethyl dihydrogen phosphate (HAP@AEPH2-SO3H) as a reusable solid acid for direct esterification of carboxylic acids with alcohols

Sulfonated nanohydroxyapatite functionalized with 2-aminoethyl dihydrogen phosphate (HAP@AEPH2-SO3H) efficiently catalyzed direct esterification of carboxylic acids and alcohols with high selectivity toward the formation of esters in good to excellent yields. Our results clearly show that HAP@AEPH2-SO3H can be easily recovered by simple filtration and reused for subsequent five runs without any significant impact on yields of products. The main advantage of this methodology is easy and ecofriendly catalyst preparation, easy catalyst separation, practical simplicity, safe reaction conditions, recyclable catalyst and high products yields.

Solvent and structural effects on the activation parameters of the reaction of carboxylic acids with diazodiphenylmethane

The kinetics of the reaction of benzoic, 2-methylbenzoic, phenylacetic, cyclohex-1-enecarboxylic, 2-methylcyclohex-1-enecarboxylic, and cyclohex-1-eneacetic acids with diazodiphenylmethane was studied at 30, 33, 37, 40, and 45°C in a set of 12 protic and aprotic solvents. The reactions were found to follow the second-order kinetics. The activation energy as well as the activation parameters, such as the standard entropy, the standard enthalpy, and the standard Gibbs energy of the activation, was calculated from the second-order rate constants. The solvent and structural effects on the activation energy and the standard Gibbs energy of activation, for each examined compound, were analyzed. The results of Kamlet-Taft multiple correlation analysis show that the specific solvent-solute interactions play a dominant role in the governing of the reaction. The signs of the equation coefficients support the proposed reaction mechanism.

DDQ-catalyzed oxidative C-O coupling of sp3 C-H bonds with carboxylic acids

Da-ddy, DDQ: By using catalytic amounts of DDQ combined with MnO 2 as oxidant, an efficient oxidative C-O coupling of benzylic sp 3 C-H bonds with carboxylic acids affords a series of carboxylic esters in 70-98 % yields. A wide range

Facile new methods for introduction and removal of the diphenylmethyl group as a protective group of carboxylic acids

Easy new methods for introducing and removing the diphenylmethyl group as a protective group of carboxylic acids are presented. For the formation of the diphenylmethyl esters from the carboxylic acids and benzhydrol, the unusual A(AL)2 mechanism is followed.