3987-39-1

Usage

Chemical structure

1,3-Benzenedicarboxylic acid, 4-[(4-carboxyphenyl)sulfonyl]-

Type of compound

Prodrug

Metabolism

Inactive until metabolized in the body

Metabolite components

5-aminosalicylic acid (5-ASA) and sulfapyridine

Properties of metabolites

Anti-inflammatory and immunosuppressive

Medical use

Treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn's disease

Mechanism of action

Reduces inflammation in the intestines and inhibits the production of certain chemicals that cause inflammation

Dosage forms

Available in oral dosage forms

Combination therapy

Often used in combination with other medications to manage symptoms

Relevant academic research and scientific papers

Antiallergic cyclic sulphur compounds

Certain tricyclic thioxanthone-10,10-dioxide compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.

Cyclic sulphur compounds

Certain tricyclic thioxanthone-10,10-dioxide compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.