39887-30-4

Upstream product

• 107-10-8 propylamine 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 619-58-9 4-iodobenzoic acid 
• 281668-97-1 4-iodo-N-allylaminocarbonylbenzene 
• 1711-02-0 4-iodobenzoic acid chloride 

Downstream Products

• 39887-76-8 N-(n-Propyl)-4-iodbenzimidylchlorid 
• 10546-70-0 N-(n-propyl)benzamide 
• 572923-17-2 4-(4-phenyl-2-oxo-oxazolidin-3-yl)-N-propyl-benzamide 
• 1448008-10-3 C₁₅H₂₁NOSi 
• 876747-69-2 4-(2,2-dioxo-4-phenyl-1,2,3-oxathiazolidin-3-yl)-N-(propyl)benzamide 
• 876747-67-0 4-(2-oxo-4-phenyl-1,2,3-oxathiazolidin-3-yl)-N-(propyl)benzamide 
• 876747-64-7 4-(2-hydroxy-1-phenylethylamino)-N-(propyl)benzamide 

Relevant academic research and scientific papers

CRF RECEPTOR ANTAGONISTS AND METHODS OF USE

Compounds are provided herein that antagonize corticotropin-releasing factor (CRF) receptors, in particular CRF receptor 1 (CRF1), as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).

Cobalt-catalyzed alkene hydrogenation by reductive turnover

Earth abundant metal catalysts hold advantages in cost, environmental burden and chemoselectivity over precious metal catalysts. Differences in reactivity for a given metal center result from ligand field strength, which can promote reaction through either open- or closed-shell carbon intermediates. Herein we report a simple protocol for cobalt-catalyzed alkene reduction. Instead of using an oxidative turnover mechanism that requires stoichiometric hydride, we find a reductive turnover mechanism that requires stoichiometric proton. The reaction mechanism appears to involve coordination and hydrocobaltation of terminal alkenes.

Highly Ag+ selective tripodal Gold(I) acetylide-based "off-On" luminescence chemosensors based on 3(ππ*) emission switching

Newly prepared gold(I) acetylide-based luminescent cation sensors 1c and 1d, which bear a novel three-armed flexible conformation, together with control molecule 2c, were synthesized in four steps. 1c and 1d exhibit the π → π* absorption of the acetylide

A mild and clean method for oxidative formation of amides from aldehydes and amines

A metal-free direct oxidative formation of amides from aldehydes and amines using a hypervalent iodine(III) reagent or an ion-supported hypervalent iodine(III) reagent as a recyclable oxidant under mild conditions is reported. Georg Thieme Verlag Stuttgart.

A new strategy for preparing molecular imaging and therapy agents using fluorine-rich (fluorous) soluble supports

A convenient new strategy for producing radiolabeled compounds in high effective specific activity was developed using soluble fluorous supports. The reported methodology involves a fluorous linker group that is released from the substrate of interest upon reaction with radioiodine. The desired product can then be selectively separated from unreacted starting material and reaction byproducts using a simple fluorous solid-phase extraction procedure. The utility of this approach was demonstrated by labeling a series of benzoic acid derivatives which are commonly used to prepare molecular imaging agents. All compounds were produced in high radiochemical yields, purities, and effective specific activities. The strategy was further elaborated in that it was used to prepare a small collection of radiolabeled benzamides as a way of demonstrating the potential utility of this method for creating libraries of molecular imaging agents. Copyright