39891-74-2Relevant academic research and scientific papers
Mechanistic study of the titanocene(III)-catalyzed radical arylation of epoxides
Gans?uer, Andreas,Von Laufenberg, Daniel,Kube, Christian,Dahmen, Tobias,Michelmann, Antonius,Behlendorf, Maike,Sure, Rebecca,Seddiqzai, Meriam,Grimme, Stefan,Sadasivam, Dhandapani V.,Fianu, Godfred D.,Flowers, Robert A.
supporting information, p. 280 - 289 (2015/08/19)
An atom-economical and catalytic arylation of epoxide-derived radicals is described. The key step of the catalytic system is a sequential electron and proton transfer for the rearomatization of the radical σ-complex and catalyst regeneration. Kinetic, computational, spectroscopic, and cyclo-voltammetric investigations highlight the key issues of the reaction mechanism and catalyst stabilization by collidine hydrochloride. Studies employing radicophiles rule out the participation of cations as reactive intermediates.
