399-77-9 Usage
Uses
Used in Organic Synthesis:
1H-Benzimidazole,5-methyl-2-(trifluoromethyl)-(9CI) is used as a key intermediate in organic synthesis for the development of new chemical entities. Its unique structure allows for the creation of a variety of compounds with potential applications in different fields.
Used in Pharmaceutical Research:
In pharmaceutical research, 1H-Benzimidazole,5-methyl-2-(trifluoromethyl)-(9CI) is utilized as a building block for the design and synthesis of novel drug candidates. Its potential pharmacological properties make it a promising candidate for the development of new therapeutic agents.
Used in Agrochemical Industry:
1H-Benzimidazole,5-methyl-2-(trifluoromethyl)-(9CI) may also have applications in the agrochemical industry. Its unique chemical properties could be harnessed for the development of new agrochemical products, such as pesticides or herbicides, although further research is required to explore these possibilities.
Used in Chemical and Biological Systems:
Due to its high electronegativity and lipophilicity, 1H-Benzimidazole,5-methyl-2-(trifluoromethyl)-(9CI) can be used to study the effects of trifluoromethyl substitution on the reactivity and bioavailability of compounds in various chemical and biological systems. This can provide valuable insights into the design of more effective and targeted therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 399-77-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 399-77:
(5*3)+(4*9)+(3*9)+(2*7)+(1*7)=99
99 % 10 = 9
So 399-77-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3N2/c1-5-2-3-6-7(4-5)14-8(13-6)9(10,11)12/h2-4H,1H3,(H,13,14)
399-77-9Relevant academic research and scientific papers
Fe(OTf)3-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles from o-arylenediamines and hexafluoroacetylacetone
Zhou, Yanmei,Shen, Guanshuo,Sui, Yuebo,Zhou, Haifeng
supporting information, p. 3396 - 3399 (2016/07/11)
An iron-catalyzed practical synthesis of 2-trifluoromethylarylimidazoles through condensation of o-arylenediamines and hexafluoroacetylacetone followed by intramolecular addition and C–C bond cleavage in one-pot has been developed. A series of title compounds were obtained with up to 99% yield. This method is quite practical and suitable for scalable preparation due to simple experimental procedure and readily available reagents.
Full length article
Bougrin, Khalid,Loupy, André,Petit, Alain,Daou, Boujemaa,Soufiaoui, Mohamed
, p. 163 - 168 (2007/10/03)
Cyclocondensation of N-(carbotrifluoromethyl)-ortho-arylenediamines leads to a series of 2-trifluoromethylarylimidazoles with good yields on montmorillonite K10 in 'dry media' under microwave irradiation within 2 min in a domestic oven. By conventional heating in the same conditions, no reaction is observed.
