39903-01-0

Basic information

• Product Name: 2-Hydroxy-3-amino-5-bromopyridine
• Synonyms: 2-Amino-5-bromo-3-pyridinol;2-Hydroxy-3-amino-5-bromopyridine;2-Amino-5-bromo-3-hydroxypyridine;2-Hydroxy-3-amino-5-bromo pyridine ,97%;5-Bromo-3-hydroxy-2-aminopyridine;3Hydroxy-2-aMino-5-broMopyridine;3-Pyridinol, 2-aMino-5-broMo-;EOS-61763
• CAS NO: 39903-01-0
• Molecular Formula: C₅H₅BrN₂O
• Molecular Weight: 189.01
• EINECS: -0
• Mol File: 39903-01-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 204-207℃
• Boiling Point: 295.13 °C at 760 mmHg
• Flash Point: 132.29 °C
• Appearance: Off-white/Solid
• Density: 1.898
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.48±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Hydroxy-3-amino-5-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-amino-5-bromopyridine(39903-01-0)
• EPA Substance Registry System: 2-Hydroxy-3-amino-5-bromopyridine(39903-01-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• Hazardous Substances Data: 39903-01-0(Hazardous Substances Data)

Usage

Uses

2-Amino-5-bromo-3-hydroxypyridine is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C5H5BrN2O/c6-3-1-4(9)5(7)8-2-3/h1-2,9H,(H2,7,8)

Upstream product

• 754230-78-9 3-(benzyloxy)-5-bromopyridine-2-amine 

Downstream Products

• 364385-30-8 4-(6-bromooxazolo[4,5-b]pyridin-2-yl)benzonitrile 
• 364385-38-6 2-[(1-benzyl-4-piperidinyl)methyl]-6-bromooxazolo[4,5-b]pyridine 
• 364385-39-7 2-[(1-benzyl-4-piperidinyl)ethyl]-6-bromooxazolo[4,5-b]pyridine 
• 1207175-73-2 5-bromo-3-hydroxy-2-tert-butyloxycarbonylaminopyridine 
• 877399-52-5 crizotinib 
• 756503-69-2 (±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine 
• 174469-41-1 6-bromo-2-phenyloxazolo<4,5-b>pyridine 
• 947249-13-0 5-bromo-3-(difluoromethoxy)pyridin-2-amine 
• 1448326-33-7 5-bromo-3-[1 (R)-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine 
• 1454852-78-8 2-(1-((2-amino-5-bromopyridin-3-yl)oxy)ethyl)-4-fluorobenzoic acid methyl ester 
• 877400-66-3 (+/-)-PF023401066 

Relevant articles and documents

Synthesis and in-vitro anti-hepatitis B virus activity of ethyl 6-Bromo-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylates

A series of ethyl 6-bromo-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Nearly half of the tested compounds were proved to be highly effective in inhibiting the replication of HBV DNA with IC50 values ranging from 1.3 to 9.1 μM. Among them, 10o and 10s were identified as the most promising compounds.