39920-37-1 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 39920-37-1 differently. You can refer to the following data:
1. white to yellow crystalline mass
2. The dichlorophenyl isocyanates are combustible, crystalline (sugar or sand-like) solids. In general, they
are white to yellow in color, but the 1,4-dichloro-2-phenyl
isomer is white to light green. Their flash points are
generally .113C but that of the 1,3-dichloro-2-phenyl isomer is reported as 77C. These chemicals are insoluble in
water, and some may be reactive. 1,2-dichloro-4-isomer
(CAS 102-36-3) is the isomer of regulatory focus
Uses
2,6-Dichlorophenyl isocyanate has been used in the preparation of pyridine-urea analog.
Potential Exposure
Those materials used as chemical
intermediates
Shipping
UN2250 Dichlorophenyl isocyanates, Hazard
Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
May form explosive mixture with air.
Isocyanates are highly flammable and reactive with many
compounds, even with themselves. Incompatible with
oxidizers (chlorates, nitrates, peroxides, permanganates,
perchlorates, chlorine, bromine, fluorine, etc.); contact may
cause fires or explosions. Reaction with moist air, water or
alcohols may form amines and insoluble polyureas and
react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time,
may generate a violent release of heat increasing theconcentration of fumes in the air. Incompatible with
amines, aldehydes, alkali metals, ammonia, carboxylic
acids, caprolactum, alkaline materials, glycols, ketones,
mercaptans, hydrides, organotin catalysts, phenols, strong
acids, strong bases, strong reducing agents such as
hydrides, urethanes, and ureas. Elevated temperatures or
contact with acids, bases, tertiary amines, and acylchlorides may cause explosive polymerization. Contact
with metals may evolve flammable hydrogen gas. Attacks
some plastics, rubber, and coatings.
Waste Disposal
Combustion in an incinerator
equipped with afterburner and fume scrubber
Check Digit Verification of cas no
The CAS Registry Mumber 39920-37-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,9,2 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 39920-37:
(7*3)+(6*9)+(5*9)+(4*2)+(3*0)+(2*3)+(1*7)=141
141 % 10 = 1
So 39920-37-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H3Cl2NO/c8-5-2-1-3-6(9)7(5)10-4-11/h1-3H
39920-37-1Relevant articles and documents
SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME
-
Paragraph 0709, (2019/02/15)
The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.
Investigation of novel pesticides with insecticidal and antifungal activities: Design, synthesis and SAR studies of benzoylpyrimidinylurea derivatives
Chen, Peiqi,Song, Xiangmin,Fan, Yongmei,Kong, Weihao,Zhang, Hao,Sun, Ranfeng
, (2018/09/10)
In order to find pesticides with insecticidal and antifungal activities, a series of novel benzoyl pyrimidinylurea derivatives were designed and synthesized. All target compounds were identified by 1H-NMR spectroscopy and HRMS. Insecticidal and antifungal activity of these compounds were evaluated and the structure-activity relationships (SAR) were clearly and comprehensively illustrated. Compound 7, with low toxicity to zebrafish (LC50 = 378.387 μg mL?1) showed 100% inhibition against mosquito (Culex pipiens pallens) at 0.25 μg mL?1. Both compounds 19 and 25 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 13 phytopathogenic fungi), which were better than those of the commercial pesticide pyrimethanil (>50% inhibitory activities against eight phytopathogenic fungi). Furthermore, compounds 19 and 25 exhibited protective activity against Sclerotinia sclerotiorum on leaves of Brassica oleracea L. during in vivo experiments.
Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton
Matsumoto, Yotaro,Noguchi-Yachide, Tomomi,Nakamura, Masaharu,Mita, Yusuke,Numadate, Akiyoshi,Hashimoto, Yuichi
, p. 1449 - 1463 (2013/08/23)
Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.