39929-79-8

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol
• Synonyms: 1H-PYRROLO-[2,3-D]-PYRIMIDINE-2,4(3H,7H)-DIONE;1,7-DIHYDRO-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIONE;2,4-Dihydroxy-1H-pyrrolo[2,3-d]pyrimidine;2,4-Dihydroxy-7-deazapurine;7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol;4,6-DIHYDROXY PYRROLO PYRIMIDINE;2,4-Dihydroxy-7H-pyrrolo-(2,3-d)pyrimidine;2,4-Dihydroxy-7H-pyrrolo[2,3-d]pyrimidine, 2,6-Dihydroxy-7-deazapurine
• CAS NO: 39929-79-8
• Molecular Formula: C₆H₅N₃O₂
• Molecular Weight: 151.12
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates;Nucleotides;Fused Ring Systems;Heterocycle-Pyrimidine series
• Mol File: 39929-79-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: >250°C
• Appearance: Pink to brown solid
• Density: 1.774 g/cm³
• Refractive Index: 1.863
• Storage Temp.: -20°C Freezer
• PKA: 11.22±0.20(Predicted)
• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol(39929-79-8)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol(39929-79-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 39929-79-8(Hazardous Substances Data)

Usage

Uses

2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

InChI:InChI=1/C6H5N3O2/c10-5-3-1-2-7-4(3)8-6(11)9-5/h1-2H,(H3,7,8,9,10,11)

Upstream product

• 107-20-0 2-chloroethanal 
• 873-83-6 6-amino-2,4-dihydroxypyrimidine 
• 271-70-5 7H-pyrrolo[2,3-d]pyrimidine 
• 3680-71-5 7-deazahypoxanthine 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 90057-09-3 2,4-dimethoxy-7H-pyrrolo<2,3-d>pyrimidine 
• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 57-13-6 urea 
• 102879-75-4 4-Amino-2,6-dihydroxy-5-(2,2-diethoxy-ethyl)-pyrimidin 

Downstream Products

• 90213-66-4 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 
• 1245811-22-6 2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-ol 
• 1245811-24-8 2-((2-chloro-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1377432-82-0 2-((2-chloro-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1245810-97-2 2-((2-((R)-3-aminopiperidin-1-yl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1245811-15-7 2-((2-((R)-3-aminopiperidin-1-yl)-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1377432-83-1 tert-butyl ((3R)-1-(3-(2-cyanobenzyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1377432-85-3 tert-butyl ((3R)-1-(3-(2-cyanobenzyl)-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1377432-86-4 tert-butyl ((3R)-1-(6-bromo-3-(2-cyanobenzyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1377432-87-5 tert-butyl ((3R)-1-(3-(2-cyanobenzyl)-4-oxo-6-(4-(trifluoromethyl)phenyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1377432-88-6 tert-butyl ((3R)-1-(3-(2-cyanobenzyl)-6-(4-fluorophenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1377432-89-7 tert-butyl ((3R)-1-(3-(2-cyanobenzyl)-4-oxo-6-(pyridin-3-yl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)piperidin-3-yl)carbamate 
• 1355173-55-5 2-((2-((R)-3-aminopiperidin-1-yl)-5,6-dibromo-7-methyl-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl)methyl)benzonitrile 
• 1392847-45-8 C₂₅H₂₈Br₂N₆O₃ 

Relevant articles and documents

Synthesis and evaluation of FAK inhibitors with a 5-fluoro-7H-pyrrolo[2,3-d]pyrimidine scaffold as anti-hepatocellular carcinoma agents

Focal adhesion kinase (FAK) is a ubiquitous intracellular non-receptor tyrosine kinase, which is involved in multiple cellular functions, including cell adhesion, migration, invasion, survival, and angiogenesis. In this study, a series of 7H-pyrrolo[2,3-d

Fused-pyrimidine derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating Bruton's tyrosine kinase activity related diseases containing the same as an active ingredient

The present invention relates to a conjugated pyrimidine derivative, a method for manufacturing the same, and a pharmaceutical composition for preventing or treating Bruton′s tyrosine kinase activity-related diseases containing the same as an active ingredient. The conjugated pyrimidine derivative according to the present invention is excellent in the ability to inhibit the activity of Bruton′s tyrosine kinase or TMD80, and thus can be usefully used for prevention or treatment of diseases related to Bruton′s tyrosine kinase activity, particularly cancer or autoimmune diseases.COPYRIGHT KIPO 2019

A Anaplastic lymphoma kinase inhibitors (by machine translation)

The present invention of formula (I) compounds, of formula (I) compounds of the type (II) in the middle of the compound, of formula (III) compound and its preparation method. Formula (I) compound is a small molecule Anaplastic lymphoma kinase (Anaplastic