3993-43-9

Usage

InChI:InChI=1/C14H14O3/c1-4-7-16-12-6-5-11-9(2)8-13(15)17-14(11)10(12)3/h4-6,8H,1,7H2,2-3H3

Upstream product

• 4115-76-8 4,8-dimethyl-7-hydroxycoumarin 
• 106-95-6 allyl bromide 
• 584-08-7 potassium carbonate 

Downstream Products

• 3993-44-0 6-allyl-7-hydroxy-4,8-dimethyl-2H-chromen-2-one 
• 21902-10-3 4',5'-dihydro-4,8,5'-trimethylpsoralen 
• 893413-54-2 6-allyl-4,8-dimethyl-7-prop-2-ynyloxy-chromen-2-one 
• 3902-71-4 trioxsalen 

Relevant academic research and scientific papers

A new route to pyranocoumarins and their benzannulated derivatives

A new protocol based on sequential applications of three atom-economic processes viz. Claisen rearrangement, olefin isomerisation, and ring-closing diene metathesis has been developed to access a range of linear and angularly fused pyranocoumarin derivatives. Incorporation of enyne (in place of diene) metathesis and Diels-Alder reaction in the sequence has allowed the corresponding benzannulated derivatives to be prepared in good yields.

7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor

A photochemotherapeutic compound of the formula STR1 wherein (i) n is zero, W is a (C1-16) alkyl, alkenyl, or alkynyl linear or branched chain hydrocarbon, having no more than four O, N, or S atoms in or attached to the chain; or (ii) n is 1, W is CR or CR2, and R, R', and R" are independently H or CH3 ; or (iii) N is 2, W is CR or CR2, and R, R', and R" are independently H or CH3 ; and A, B, C, and D are independently selected from hydrogen, alkyl, aryl, halogen, amino, aminoalkyl, nitro, alkoxy, aryloxy, hydroxy, carboxy, haloalkyl, or haloalkoxy, particularly compounds of the foregoing structure in which W is a charged substiuent and n=0 or 1.

DDQ Oxidation of 6- or 8-Allyl-7-hydroxycoumarins. A New Synthesis of Benzodipyrandiones and Furobenzopyranones

A novel synthesis of 2H,8H-benzodipyran-2,8-diones, 2H,8H-benzodipyran-2,8-diones, 2H-furobenzopyran-2-ones, and 7H-furobenzopyran-7-ones was achieved by developing 2-pyrone and furan ring over coumarin. 6- or 8-Allyl-7-hydroxycoumarins on oxidation with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) afforded benzodipyrandiones and furobenzopyranones.The structures of the compounds now synthesized were established by analytical, spectral, and comparison with authentic samples prepared by the known procedures.

8-Aminoalkyl-4-alkylpsoralens

The invention relates to 8-aminoalkyl-4-alkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of different structure.