39930-51-3

Usage

Type of compound

Heterocyclic compound

Structure

Fused pyrrolopyrimidine ring system

Functionality

Potent and selective inhibitor of mitochondrial dihydroorotate dehydrogenase (DHODH)

Enzyme target

DHODH, involved in de novo pyrimidine biosynthesis

Potential therapeutic applications

Treatment of various diseases, including cancer, autoimmune disorders, and inflammatory diseases

Relevance

Of interest to researchers in the fields of medicinal chemistry and drug development

Upstream product

• 39112-72-6 1,3-Dimethylpyrrolo<2,3-d>pyrimidine-2,4-dione 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 128751-18-8 6-Amino-5-(2,2-diethoxyethyl)-1,3-dimethylpyrimidine-2,4-dione 
• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 6642-31-5 6-Amino-1,3-dimethylbarbituric acid 

Relevant academic research and scientific papers

FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. Formula (I)

Synthesis and Properties of Conformationally Locked 1,3-Bisalkyl-7-deazaxanthine 2'-Deoxy-D-ribofuranosides

1,3-Dimethyl-7-deazaxanthine 2'-deoxyribofuranoside 1a and 6a and their N-3 isopropyl congeners 1b and 6b have been prepared employing the nucleobase anions 7a or 7b and 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride (8) upon glycosylatio