39942-01-3

Basic information

• Product Name: D-(-)-Norgestrel
• Synonyms: (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-trimethylsilyloxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS NO: 39942-01-3
• Molecular Formula: C24H36O2Si
• Molecular Weight: 384.62694
• Mol File: 39942-01-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 453.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.04±0.1 g/cm3(Predicted)
• Solubility: Acetone, Dichloromethane, Methanol
• CAS DataBase Reference: D-(-)-Norgestrel(CAS DataBase Reference)
• NIST Chemistry Reference: D-(-)-Norgestrel(39942-01-3)
• EPA Substance Registry System: D-(-)-Norgestrel(39942-01-3)

Safety Data

• Hazardous Substances Data: 39942-01-3(Hazardous Substances Data)

Usage

Description

D-(-)-Norgestrel, also known as Levonorgestrel, is a synthetic progestin hormone that is the active ingredient in several contraceptive products. It is a derivative of the naturally occurring hormone progesterone and is used to prevent pregnancy by inhibiting ovulation, altering the cervical mucus, and changing the lining of the uterus.

Uses

Used in Contraceptive Applications:
D-(-)-Norgestrel is used as a contraceptive agent in various forms, including oral contraceptive pills, contraceptive patches, and vaginal rings. It is effective in preventing pregnancy when used as directed and is a popular choice for women seeking a hormonal method of birth control.
Used in Emergency Contraceptive Applications:
D-(-)-Norgestrel is also used as an emergency contraceptive, marketed under the brand name Plan B One-Step. It is taken as a single dose within 72 hours of unprotected sex to reduce the risk of pregnancy. It works by delaying or inhibiting ovulation, preventing fertilization, and altering the endometrium to make it less receptive to a fertilized egg.
Used in Hormone Replacement Therapy:
In some cases, D-(-)-Norgestrel may be used as part of hormone replacement therapy (HRT) for women experiencing menopause. It can help alleviate symptoms such as hot flashes and vaginal dryness while providing the benefits of a progestin hormone.
Used in Treatment of Heavy Menstrual Bleeding:
D-(-)-Norgestrel has also been used to treat heavy menstrual bleeding (menorrhagia) in women who have not undergone hysterectomy. It can help regulate menstrual cycles and reduce the amount of bleeding during menstruation.
Overall, D-(-)-Norgestrel is a versatile hormone with various applications in reproductive health, contraception, and hormone therapy. Its effectiveness and safety have made it a widely used option for women's health.