39953-67-8Relevant academic research and scientific papers
One-step synthesis of isoindolo[2,1- a]indol-6-ones via tandem Pd-catalyzed aminocarbonylation and C-H activation
?arny, Tomá?,Markovi?, Martin,Gracza, Tibor,Koó?, Peter
, p. 12499 - 12507 (2019)
A unified catalytic system for tandem Pd-catalyzed carbonylation and C-C cross-coupling via C-H activation was designed. The proposed cascade reaction allows a facile one-step construction of a tetracyclic isoindoloindole skeleton, in which three new C-C/C-N bonds are simultaneously formed. In detail, the carbonylation of aryl dibromides with indoles and C-H activation of in situ formed N-(2'-bromoaroyl)-indole provide biologically relevant 6H-isoindolo[2,1-a]indol-6-ones from commercially available substrates. The aminocarbonylation step in the proposed tandem reaction utilizes glyoxylic acid monohydrate as an environmentally friendly CO surrogate.
A new approach to pyrrolophenanthridone alkaloids via intramolecular radical cyclization
Tsuge, Otohiko,Hatta, Taizo,Tsuchiyama, Hiroshi
, p. 155 - 156 (2007/10/03)
A new approach to the synthesis of pyrrolophenanthridone class of alkaloids is described. The method is based on intramolecular radical cyclization of easily accessible 1-aroyl-7-bromoindoles with Bu3SnH and AIBN.
