39954-65-9

Usage

Chemical structure

A quinolinium core structure with a side chain consisting of a 2-oxoethyl group with a 4-methoxyphenyl substituent.

Family

Belongs to the quinolinium family, which is known for its biological and pharmaceutical relevance.

Potential applications

Studied for their potential use in medicinal chemistry, particularly in the development of antimicrobial, antimalarial, and anticancer agents.

Pharmacological properties

The presence of the 4-methoxyphenyl group may impart specific pharmacological properties to the compound.

Structure modification

Its structure could potentially be modified to enhance its biological activity.

Field of exploration

Has potential for further exploration in the field of medicinal chemistry and drug development.

Upstream product

• 91-22-5 quinoline 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 1227796-79-3 1-(4-methoxybenzoyl)pyrrolo[1,2-a]quinoline 

Relevant academic research and scientific papers

Synthesis and biological screening of new cyano-substituted pyrrole fused (Iso)quinoline derivatives

Several new cyano-substituted derivatives with pyrrolo[1,2-a]quinoline and pyrrolo[2,1a]isoquinoline scaffolds were synthesized by the [3 + 2] cycloaddition of (iso)quinolinium ylides to fumaronitrile. The cycloimmonium ylides reacted in situ as 1,3-dipol

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions

1-Benzoyl-3-cyanopyrrolo[1,2-a]quinoline (2a) was identified as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 2a had good activity against several breast cancer cell lines but was much less active

Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives

New derivatives of quinoline (CAS 91-22-5, Z-1) were synthesized and their potential therapeutical significance and structure-activity relationship were tested. The brine shrimp bioassay was carried out to study their in vitro cytotoxicity, and besides, a