399580-48-4

Basic information

• Product Name: (2-(trifluoroMethoxy)phenyl)acrylic acid
• Synonyms: (2-(trifluoroMethoxy)phenyl)acrylic acid;2-[2-(trifluoroMethoxy)phenyl]prop-2-enoic acid;(E)-3-(2-(TRIFLUOROMETHOXY)PHENYL)ACRYLIC ACID
• CAS NO: 399580-48-4
• Molecular Formula: C10H7F3O3
• Molecular Weight: 232
• Mol File: 399580-48-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 281.305 °C at 760 mmHg
• Flash Point: 123.929 °C
• Appearance: /
• Density: 1.403 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-(trifluoroMethoxy)phenyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-(trifluoroMethoxy)phenyl)acrylic acid(399580-48-4)
• EPA Substance Registry System: (2-(trifluoroMethoxy)phenyl)acrylic acid(399580-48-4)

Safety Data

• Hazardous Substances Data: 399580-48-4(Hazardous Substances Data)

Usage

General Description

(2-(Trifluoromethoxy)phenyl)acrylic acid, also known as TFMPAA, is a chemical compound with the molecular formula C9H7F3O3. It is a white solid with a molecular weight of 214.15 g/mol. TFMPAA is used in the synthesis of various pharmaceutical compounds, agrochemicals, and organic materials. It is a versatile building block for the preparation of fluorinated organic molecules and is often used as a reagent in organic synthesis. TFMPAA is also used as a precursor in the production of specialty polymers and other advanced materials. Overall, TFMPAA plays a crucial role in the development and production of various important chemicals and materials.

Upstream product

• 141-82-2 malonic acid 

Relevant articles and documents

Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives

This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF3, OCF3, F) on the meta- of the benzyl ring of barbituric acid derivatives led to a considerable increase in the antiproliferative activities compared with that of corresponding ortho- and para-substituted barbituric acid derivatives. Mechanism investigation implied that the 1c could increase the ROS and MDA level, decrease the ratio of GSH/GSSG and MMP, and lead to cell cycle arrest. Further research is needed for structural optimization to enhance hydrophilicity, thereby improve the biological activity of these compounds.