39971-69-2

Basic information

• Product Name: Methanone, (3,4-dimethoxyphenyl)-1-isoquinolinyl-
• CAS NO: 39971-69-2
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.322
• Mol File: 39971-69-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (3,4-dimethoxyphenyl)-1-isoquinolinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (3,4-dimethoxyphenyl)-1-isoquinolinyl-(39971-69-2)
• EPA Substance Registry System: Methanone, (3,4-dimethoxyphenyl)-1-isoquinolinyl-(39971-69-2)

Safety Data

• Hazardous Substances Data: 39971-69-2(Hazardous Substances Data)

Upstream product

• 119-65-3 isoquinoline 
• 4732-70-1 3,4-dimethoxyphenylglyoxylic acid 
• 88422-82-6 1-(3',4'-dimethoxybenzyl)-3,4-dihydroisoquinoline 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1532-72-5 isoquinoline N-oxide 
• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 

Downstream Products

• 39949-78-5 1-(3,4-dimethoxy-phenyl)-oxazolo[4,3-a]isoquinolin-3-one 

Relevant articles and documents

Minisci aroylation of N-heterocycles using choline persulfate in water under mild conditions

Metal persulfate mediated thermal oxidative organic transformations invariably require a higher temperature and frequently use an organic solvent. The objective of this work was to develop persulfate mediated oxidative transformations that can be performed nearly at room temperature using water as a solvent. This report describes modified Minisci aroylation of isoquinolines with arylglyoxylic acids using choline persulfate and its pre-composition (choline acetate and K2S2O8) in water at 40 °C. A few other nitrogen heterocycles were also utilized affording various aroylated products in good to excellent yields. Unlike metal persulfate that could produce metal salt byproducts, a key feature of the chemistry reported herein includes the use of environmentally benign choline persulfate containing biodegradable choline as a counter-cation, the Minisci reaction demonstrated at 40 °C in water as the only solvent, and unconventional activation of persulfate. This journal is

Palladium(II)-catalyzed C-C and C-O bond formation for the synthesis of C1-benzoyl isoquinolines from isoquinoline: N -oxides and nitroalkenes

C1-Benzoyl isoquinolines can be generated via a palladium(ii)-catalyzed C-C and C-O coupling of isoquinoline N-oxides with aromatic nitroalkenes. The reaction proceeds through remote C-H bond activation and subsequent intramolecular oxygen atom transfer (OAT). In this reaction, the N-O bond was designed as a directing group in the C-H bond activation as well as the source of an oxygen atom.

TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C1-acyl substituted heterocycles in good efficiency.