39978-35-3Relevant academic research and scientific papers
38. Approaches to the Synthesis of Cytochalasans. Part 4. Improved Synthesis of the Tetrahydroisoindoline Subunits Related to the Cytochalasins and Aspochalasins
Schmidlin, Tibur,Bruckhardt, Peter E.,Waespe-Sarcevic, Nada,Tamm, Christoph
, p. 450 - 465 (2007/10/02)
A general scheme for the synthesis of the tetrahydroisoindolinone moiety of naturally occurring cytochalasans and unnatural analogs was developed.The keystep consist of the intermolecular cycloaddition of 4-methylsorbinol (7) to an alkylidene malonic
