39989-43-0

Basic information

• Product Name: 3,5-Dichlorobenzylamine
• Synonyms: 3,5-DICHLOROBENZYLAMINE;RARECHEM AL BW 0159;(3,5-Dichlorophenyl)methanamine;3,5-Dichlorobenzylamine,97%;3,5-Dichlorobenzenemethanamine;3,5-Dichlorobenzylam;(3,5-Dichlorophenyl)methylamine
• CAS NO: 39989-43-0
• Molecular Formula: C₇H₇Cl₂N
• Molecular Weight: 176.04
• EINECS: -0
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 39989-43-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 116 °C
• Flash Point: 141-144°C/15mm
• Appearance: /
• Density: 1.32
• Refractive Index: 1.575
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.48±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 3237459
• CAS DataBase Reference: 3,5-Dichlorobenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichlorobenzylamine(39989-43-0)
• EPA Substance Registry System: 3,5-Dichlorobenzylamine(39989-43-0)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 39989-43-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to yellow liquid

Uses

3,5-Dichlorobenzylamine can be used as modulators of 5''-nucleotidase as a chemotherapeutic agent.

InChI:InChI=1/C7H7Cl2N/c8-6-1-5(4-10)2-7(9)3-6/h1-3H,4,10H2

Upstream product

• 10203-08-4 3,5-dichlorobenzaldehyde 
• 100-46-9 benzylamine 
• 93033-57-9 3,5-dichlorobenzaldehyde oxime 

Downstream Products

• 867281-16-1 3-bromo-N-(3,5-dichlorobenzyl)-4-(fluoromethoxy)benzenecarboximidamide 
• 1185653-04-6 N-(4-(3,5-dichlorobenzylamino)-2-oxobutyl)-2-naphthamide 
• 100-46-9 benzylamine 
• 903581-41-9 2-(3,5-dichlorobenzylamino)-4-fluoro-nitrobenzene 
• 903581-45-3 N-(3,5-dichlorobenzyl)-5-fluoro-2-(methylsulfonyl)benzenamine 
• 903580-87-0 1-(2-(3,5-dichlorobenzylamino)-4-fluorophenyl)-2,2,2-trifluoroethanone 
• 904310-95-8 4-amino-5-cyano-N-(3,5-dichlorobenzyl)-6-ethoxypyridine-2-carboxamide 
• 871939-59-2 N-[(3,5-dichlorophenyl)methyl]-2,2-bis(methyloxy)ethanamine 
• 852880-50-3 1,1-dimethylethyl 4-{1-[(3,5-dichlorophenyl)-methyl]-2-oxo-3-pyrrolidinyl}-4-(4-fluorophenyl)-1-piperidinecarboxylate 

Relevant articles and documents

Synthesis method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride

The invention relates to a synthesis method of 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride, and belongs to the technical field of synthesis of medical intermediates. The method comprises the steps that 3, 5-dichlorobenzaldehyde serves as a raw material, 5, 7-dichloro-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride is obtained through Schiff base preparation, reduction, ring closing and reductive acidification reaction, and the total yield is 60% or above. The method avoids using expensive raw materials, and is simple in process route, mild in condition, low in production costand suitable for industrial production.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.