39996-87-7

Basic information

• Product Name: Diethyl [(2-pyridinyl)methyl]phosphonate
• Synonyms: Diethyl [(2-pyridinyl)methyl]phosphonate;2-(Diethoxyphosphorylmethyl)pyridine
• CAS NO: 39996-87-7
• Molecular Formula: C₁₀H₁₆NO₃P
• Molecular Weight: 229.212701
• Mol File: 39996-87-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 332.1°C at 760 mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 0.000287mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: Diethyl [(2-pyridinyl)methyl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl [(2-pyridinyl)methyl]phosphonate(39996-87-7)
• EPA Substance Registry System: Diethyl [(2-pyridinyl)methyl]phosphonate(39996-87-7)

Safety Data

• Hazardous Substances Data: 39996-87-7(Hazardous Substances Data)

Usage

General Description

Diethyl [(2-pyridinyl)methyl]phosphonate is a chemical compound with the formula C11H16NO3P. It is a phosphonate ester that is often used as an intermediate in the synthesis of various organic compounds. This chemical is known for its diverse applications in the pharmaceutical and agrochemical industries, where it is used as a building block in the production of pesticides, herbicides, and pharmaceutical drugs. Diethyl [(2-pyridinyl)methyl]phosphonate is also used in the development of chiral ligands for asymmetric catalysis and as a precursor for the synthesis of biologically active molecules. Its unique structure and properties make it a valuable and versatile compound in the realm of organic chemistry.

InChI:InChI=1/C10H16NO3P/c1-3-13-15(12,14-4-2)9-10-7-5-6-8-11-10/h5-8H,3-4,9H2,1-2H3

Upstream product

• 4377-33-7 2-chloromethylpyridine 
• 122-52-1 triethyl phosphite 
• 762-04-9 phosphonic acid diethyl ester 

Downstream Products

• 1416861-34-1 (E)-(4aR,7R,8aS)-7-methyl-1-[(4-methylbenzene)sulfonyl]-5-(pyridin-2-ylmethylidene)decahydroquinoline 
• 1416861-41-0 (Z)-(4aR,7R,8aS)-7-methyl-1-[(4-methylbenzene)sulfonyl]-5-(pyridin-2-ylmethylidene)decahydroquinoline 
• 21882-07-5 Cu(pyridine-2-carboxylate)2 C12H8CuN2O4, violet 
• 129078-90-6 <(1-benzylpyridino)-2-methyl>phosphonic acid 
• 1262049-27-3 (5R,8S,11R,13S,14S,17S)-5',5',13-trimethyl-17-(pentafluoroethyl)-11-{4-[2-(pyridin-2-yl)ethyl]phenyl}-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17-diol 
• 1262049-28-4 (5R,8S,11R,13S,14S,17S)-5',5',13-trimethyl-17-(pentafluoroethyl)-11-{4-[(E)-2-(pyridin-2-yl)ethenyl]phenyl}-1,2,3,4,6,7,8,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2'-[1,3]dioxane]-5,17-diol 

Relevant articles and documents

Utilities of olefin derivatives

Compounds having an activity to enhance the expression of apoAI are provided. Compounds of formula (I): in which Ar1 and Ar2 are independently a phenyl, naphthyl, or monocyclic or bicyclic aromatic heterocyclic group, which may be optionally substituted; —X— is —N═CZ2-, —CY2═CZ2-, —CY2Y3—CHZ2-, —S—, —O—, or the like; Y1, Y2, Y3, Z1 and Z2 are independently a hydrogen, a halogen, a lower alkyl, a phenyl, or the like; Z1 and Z2 may be independently a linker group that may combine with Ar2 and Ar1 to form a condensed ring; m is 0 or 1, and n is 0 to 2; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them; are disclosed.

A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES

The Michaelis-Becker-Nylen reaction is well suited for the synthesis of 2-phosphonomethyl pyridines.We have improved this four steps method in a one pot reaction using commercial reagents.By this general procedure we have prepared seven new 2-phosphonomethyl pyridines (Ia-g) under mild conditions with higher yields.Key words: 2-phosphono pyridines; 2-phosphonomethyl pyridines; Michaelis-Becker-Nylen reaction; new phosphonates; potential ligands.

Photolysis of Pyridylmethyl- and Pyridiniomethylphosphonic Acids

Upon UV-irradiation, the C-P bond of (4-pyridylmethyl)phosphonic acid cleaved only near the isoelectronic point to give 4-methylpyridinium phophate, while (1-benzyl-4-pyridiniomethyl)phosphonic acid underwent C-P bond cleavage above pH 4 to give 1-benzyl-4-methylpyridinium phosphate.On the other hand, the C-P bond of (2-pyridylmethyl)phosphonic acid cleaved under pH region of about 1 to 2, while (1-benzyl-2-pyridiniomethyl)phosphonic acid underwent C-P bond cleavage above pH4.