400-74-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-5-nitrobenzotrifluoride is used as a synthetic intermediate for the synthesis of [3-(4-nitro-2-trifluoromethylphenyl)aminophenyl]dihydroxyborane, which can be further utilized in the development of pharmaceutical compounds. Its unique chemical structure allows it to serve as a building block for creating novel molecules with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Fluoro-5-nitrobenzotrifluoride can be employed as a versatile reagent for the creation of various organic compounds. Its fluoro and nitro groups provide opportunities for further functionalization and modification, making it a valuable component in the synthesis of complex molecules.
Used in Research and Development:
Due to its unique properties and potential applications, 2-Fluoro-5-nitrobenzotrifluoride can be used in research and development for exploring new chemical reactions, understanding its reactivity, and identifying novel applications in different industries.

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 6034, 1956 DOI: 10.1021/ja01604a022

InChI:InChI=1/C8H6FNO3/c1-5(11)6-2-3-7(9)8(4-6)10(12)13/h2-4H,1H3

Upstream product

• 360-74-7 4,4'-dinitro-2,2'-bis(trifluoromethyl)diphenyl sulphone 
• 150690-61-2 4-chloro-4'-nitro-2'-trifluoromethyldiphenyl sulphone 
• 777-37-7 4-chloro-3-(trifluoromethyl)nitrobenzene 

Downstream Products

• 54495-43-1 N-(4-Nitro-2-trifluormethylphenyl)glycylglycin 
• 2968-47-0 4-nitro-2-trifluoromethyl-benzenesulfonic acid 
• 2357-47-3 4-Fluoro-3-trifluoromethylaniline 
• 28698-47-7 1-(4-nitro-2-trifluoromethyl-phenyl)-piperidine 
• 54672-11-6 4-(4-nitro-2-(trifluoromethyl)phenyl)morpholine 
• 351324-52-2 1-<4-nitro-2-(trifluoromethyl)phenyl>-1H-imidazole 
• 3803-10-9 4-nitro-2-(trifluoromethyl)phenyl phenyl sulfone 
• 913829-67-1 ethyl 3,4-dihydro-7-(4-{[3-(methoxycarbonylmethyl)phenylaminocarbonyloxy]methyl}imidazol-1-yl)-3-oxo-6-(trifluoromethyl)quinoxaline-2-carboxylate 

Relevant academic research and scientific papers

Fluorodenitration of activated diphenyl sulphones using tetramethylammonium fluoride

Fluorodenitration of nitro-substituted diphenyl sulphones occurs readily in dipolar aprotic solvents using tetramethylammonium fluoride as the source of fluoride, although other reactions including fluorodesulphonylation can sometimes occur in competition. - Keywords: Fluorodenitration; Diphenyl sulphones; Tetramethylammonium fluoride; NMR spectroscopy; Mass spectrometry

Isomerisation Accompanying Fluorodenitration of Trifluoromethyl Activated Diphenyl Sulfones

Fluorodenitration of 2-(4-chlorobenzene sulfonyl)-5-nitrobenzotrifluoride using tetramethyl ammonium fluoride affords a mixture of 2-fluoro-5-nitrobenzotrifluoride and two isomers of (4-chlorobenzene sulfonyl)-fluorobenzotrifluoride.

A General Procedure for the Fluorodenitration of Aromatic Substrates

The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.