400024-77-3Relevant academic research and scientific papers
Phosphorylation of 2-(3-methyl-1,3-diazabuten-1-yl)-3-Ethoxycarbonylthiophenes with phosphorus(III) halides
Pinchuk, Alexandr M.,Kovalyova, Svetlana A.,Ivonin, Sergey P.,Merkulov, Anatoliy S.,Kudrya, Tamara N.,Chaikovskaya, Alexandra A.,Tolmachev, Andrey A.
, p. 641 - 651 (2001)
2-(3-Methyl-1,3-diazabuten-1-yl)-3-ethoxycarbonylthiophenes are phosphorylated with phosphorus(III) halides in basic media at position 5 of the thiophene ring. Up to three heteroaromatic substituents can be introduced one by one at the same phosphorus atom. On this basis, mono-, bis-, and trishetaryl substituted P(III) and P(V) derivatives have been obtained. Phosphorylated 2-(N,N-dimethylformamidino)-3-ethoxycarbonylthiophenes provide a synthetic access to phosphorylated thienopyrimidines.
