40004-69-1

Basic information

• Product Name: 2-methyl-1,3-thiazole-5-carboxylic acid
• Synonyms: 5-Thiazolecarboxylicacid, 2-Methyl-;2-methyl-1,3-thiazole-5-carboxylic acid;2-Methyl-5-thiazolecarboxylic acid;RU-21933;2-methylthiazole-5-carboxylic acid;2-methyl-1,3-thiazole-5-carboxylic acid(SALTDATA: FREE);5-Carboxy-2-methyl-1,3-thiazole
• CAS NO: 40004-69-1
• Molecular Formula: C₅H₅NO₂S
• Molecular Weight: 143.17
• Product Categories: Thiazole series;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 40004-69-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 301.2 °C at 760 mmHg
• Flash Point: 136 °C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 0.000473mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-methyl-1,3-thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1,3-thiazole-5-carboxylic acid(40004-69-1)
• EPA Substance Registry System: 2-methyl-1,3-thiazole-5-carboxylic acid(40004-69-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/39
• Safety Statements: 26-37
• RTECS: XJ3678500
• Hazardous Substances Data: 40004-69-1(Hazardous Substances Data)

Usage

Description

2-Methyl-1,3-thiazole-5-carboxylic acid is a chemical compound characterized by its molecular formula C6H7NO2S. It is a derivative of thiazole, a heterocyclic compound that features both sulfur and nitrogen atoms within its five-membered ring structure. 2-methyl-1,3-thiazole-5-carboxylic acid is recognized for its potential in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Methyl-1,3-thiazole-5-carboxylic acid is utilized as a key building block in the synthesis of pharmaceuticals and agrochemicals. Its presence in these compounds is attributed to its ability to contribute to the development of new drugs and pesticides, enhancing their efficacy and selectivity.
Used in Materials Science:
In the field of materials science, 2-methyl-1,3-thiazole-5-carboxylic acid is employed for the development of functional coatings and polymers. Its incorporation into these materials is aimed at improving their properties, such as durability, resistance to environmental factors, and specific interactions with other substances.
Used in Antimicrobial Applications:
2-Methyl-1,3-thiazole-5-carboxylic acid is used as an antimicrobial agent due to its reported antibacterial and antifungal properties. It serves to combat microbial growth in various applications, contributing to the preservation of materials and products, as well as potentially serving in healthcare and hygiene-related products.

InChI:InChI=1/C5H5NO2S/c1-3-6-2-4(9-3)5(7)8/h2H,1H3,(H,7,8)

Upstream product

• 79836-78-5 ethyl 2-methylthiazole-5-carboxylate 
• 3581-87-1 2-methylthiazole 
• 124-38-9 carbon dioxide 
• 56012-38-5 5-(hydroxymethyl)-2-methylthiazole 

Downstream Products

• 91137-85-8 2-methyl-thiazole-5-carboxylic acid anilide 
• 95074-54-7 2-methyl-thiazole-5-carbothioic acid anilide 
• 1148157-33-8 benzyl (2S)-3-methoxy-2-[(2S)-3-methoxy-2-[(2-methyl-1,3-thiazol-5-yl)formamido]propanamido]propanoate 
• 935888-69-0 N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide 
• 99979-78-9 2-methyl-thiazole-5-carboxylic acid amide 
• 53233-90-2 methyl 2-methylthiazole-5-carboxylate 
• 63140-11-4 2-methyl-5-thiazolylmethyl chloride 
• 56012-38-5 5-(hydroxymethyl)-2-methylthiazole 
• 1254968-50-7 2-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-ethyl]-thiazole-5-carboxylic acid isopropyl amide 

Relevant articles and documents

Visualizing Compartmentalized Cellular Mg2+ on Demand with Small-Molecule Fluorescent Sensors

The study of intracellular metal ion compartmentalization and trafficking involved in cellular processes demands sensors with controllable localization for the measurement of organelle-specific levels of cations with subcellular resolution. We introduce herein a new two-step strategy for in situ anchoring and activation of a fluorescent Mg2+ sensor within an organelle of choice, using a fast fluorogenic reaction between a tetrazine-functionalized pro-sensor, Mag-S-Tz, and a strained bicyclononyne conjugated to a genetically encoded HaloTag fusion protein of known cellular localization. Protein conjugation does not affect the metal-binding properties of the o-aminophenol-N,N,O-triacetic acid (APTRA)-based fluorescent indicator, which displays a dissociation constant Kd = 3.1 mM suitable for the detection of low millimolar concentrations of chelatable Mg2+ typical of the intracellular environment. We demonstrate the application of our sensing system for the ratiometric detection of Mg2+ in target organelles in HEK 293T cells, providing the first direct comparison of subcellular pools of the metal without interfering signal from other compartments. Activation of the fluorescence in situ through a fluorogenic conjugation step effectively constrains the fluorescence signal to the locale of interest, thus improving the spatial resolution in imaging applications and eliminating the need for washout of mislocalized sensor. The labeling strategy is fully compatible with live cell imaging, and provides a valuable tool for tracking changes in metal distribution that to date have been an unsolved mystery in magnesium biology.

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

GASTRO-RETENTIVE MODIFIED RELEASE DOSAGE FORMS FOR OPROZOMIB AND PROCESS TO MAKE THEREOF

This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.