400071-93-4

Basic information

• Product Name: 1-(4-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 1-(4-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE
• CAS NO: 400071-93-4
• Molecular Formula: C₁₆H₁₁BrFNO
• Molecular Weight: 0
• Mol File: 400071-93-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE(400071-93-4)
• EPA Substance Registry System: 1-(4-FLUOROBENZYL)-5-BROMO-1H-INDOLE-3-CARBALDEHYDE(400071-93-4)

Safety Data

• Hazardous Substances Data: 400071-93-4(Hazardous Substances Data)

Upstream product

• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 
• 10075-50-0 5-bromo-1H-indole 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 1283706-98-8 C₁₉H₁₃BrFN₃OS 
• 558469-91-3 5-bromo-1-(4-fluorobenzyl)-3-hydroxymethyl-1H-indole 
• 400071-97-8 5-bromo-1-(4-fluorobenzyl)indole-3-carboxylic acid 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of indole aldehydes containing N-benzyl moiety

The present study describes the synthesis, characterization and biological evaluation of N-benzyl indole aldehydes. The biological activities of the newly synthesized compounds were examined by investigating their antioxidant and anti-inflammatory activities. The potential of these compounds as an antioxidant was determined by 2,2-diphenylpicrylhydrazyl, Nitric oxide, Superoxide, peroxide radical scavenging methods. We found that aldehydes 4a, 4b, 4c, and 4e and shows promising in vitro DPPH scavenging antioxidant activity while aldehyde 4b and 4e show good in vitro anti-inflammatory activity.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

N-Pyridinyl-indole-3-(alkyl)carboxamides and derivatives as potential systemic and topical inflammation inhibitors

N-substituted-(indol-3-yl)carboxamides 10-15 and alkanamides 16-18 were prepared starting from the corresponding acids and submitted to screening for evaluation of their anti-inflammatory activity. None of the considered carboxamides exhibited significant inhibitory effect in the carrageenin-induced rat paw oedema after oral administration of 0.1 mM kg-1; nevertheless introduction of an alkyl chain, leading to alkanamides 16-18, induced moderate to high activity: 46-95% inhibition. The efficacy of these compounds in the inhibition of topical inflammation was confirmed by measuring reduction of ear thickness in the acute tetradecanoyl phorbol acetate (TPA)-induced mouse ear swelling assay. Preliminary pharmacomodulation brought to the fore that toxic effects induced, at 0.4 mM kg-1, by N-(pyridin-4-yl)(indol-3-yl)propanamide (17) could be attenuated or suppressed by 5-fluorination or introduction of a methoxycarbonylborane moiety, leading to 18 and 21.