400073-68-9

Basic information

• Product Name: Methyl N-Boc-2-oxopiperidine-3-carboxylate
• Synonyms: Methyl N-Boc-2-oxopiperidine-3-carboxylate;1-(tert-butoxycarbonyl)-3-methyl-2-oxopiperidine-3-carboxylic acid
• CAS NO: 400073-68-9
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 257.28296
• Mol File: 400073-68-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl N-Boc-2-oxopiperidine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl N-Boc-2-oxopiperidine-3-carboxylate(400073-68-9)
• EPA Substance Registry System: Methyl N-Boc-2-oxopiperidine-3-carboxylate(400073-68-9)

Safety Data

• Hazardous Substances Data: 400073-68-9(Hazardous Substances Data)

Usage

General Description

Methyl N-Boc-2-oxopiperidine-3-carboxylate is a chemical compound with the molecular formula C11H17NO5. It is a derivative of piperidine, which is a heterocyclic organic compound. The "N-Boc" in its name stands for N-tert-butoxycarbonyl, which is a protecting group used in organic synthesis. Methyl N-Boc-2-oxopiperidine-3-carboxylate is commonly used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and bioactive compounds. It is also used in research laboratories for the preparation of chemical compounds and in organic chemistry reactions. Additionally, it can be used as a building block for the synthesis of other organic molecules due to its versatile reactivity and functional group compatibility.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 675-20-7 piperidin-2-one 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 79-22-1 methyl chloroformate 
• 106412-35-5 N-benzyloxycarbonyl-2-piperidone 

Downstream Products

• 1392109-77-1 N-(tert-butoxycarbonyl)-3-[(11-tert-butyldiphenylsilyloxy)undecyl]-3-(methoxycarbonyl)-2-piperidone 
• 1392110-20-1 13-(benzyloxymethyl)-1-azabicyclo[11.3.1]heptadecane 
• 1392109-84-0 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanaldehyde 
• 1392110-19-8 13-(benzyloxymethyl)-2-oxo-1-azabicyclo[11.3.1]-heptadecane 
• 1392109-83-9 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-piperidineundecanoic acid 
• 1392109-81-7 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-(11-hydroxyundecyl)piperidine 
• 1392109-80-6 N-(tert-butoxycarbonyl)-3-[(11-tert-butyldiphenylsilyloxy)undecyl]-3-(methoxymethyl)piperidine 
• 1392109-79-3 3-(benzyloxymethyl)-N-(tert-butoxycarbonyl)-3-[(11-tertbutyldiphenylsilyloxy)undecyl]piperidine 
• 1392109-78-2 N-(tert-butoxycarbonyl)-3-[(11-tert-butyldiphenylsilyloxy)undecyl]-3-(hydroxymethyl)piperidine 
• 137031-90-4 Methyl 7-<8-methylsulphonyloxy-(Z)-oct-3-enyl>-1-oxo-8-phenylthio-1,2,3,4,4a,5,8,8a-octahydroisoquinoline-8a-carboxylate 

Relevant articles and documents

Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

The diastereoselective conjugate addition of an organocopper reagent to a chiral racemic olefinic amido ester has been used as the key step in a formal total synthesis of paroxetine.

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Model studies on the synthesis of madangamine alkaloids. Assembly of the macrocyclic rings

Using simplified model derivatives, the assembly of the macrocyclic rings of madangamines, including the 13- and 14-membered D rings of madangamines C-E, the all-cis-triunsaturated 15-membered D ring of madangamine A, and the (Z,Z)-unsaturated 11-membered E ring common to madangamines A-E, has been studied.