400073-79-2Relevant academic research and scientific papers
NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHOD OF USE THEREOF
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Page/Page column 43-44; 47, (2021/12/08)
Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation.
2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES
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Paragraph 85; 90, (2020/03/02)
A genus of compounds encompassed by formula (III) and their use is disclosed: Formula (III). The compounds activate Ppargc1a and, as a consequence, are useful for treating a variety of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, motor neuron diseases, and a demyelinating disease.
Copper-Catalyzed Double C-N Bond Formation for the Synthesis of Diverse Benzimidazoles from N -Alkyl-2-iodoaniline and Sodium Azide
Chen, Zhengkai,Li, Hongli,Cao, Gangjian,Xu, Jianfeng,Miao, Maozhong,Ren, Hongjun
, p. 504 - 508 (2017/02/24)
An efficient approach to the synthesis of benzimidazole derivatives has been achieved by copper-catalyzed double C-N bonds formation of N-alkyl-2-iodoaniline and sodium azide. The reaction was supposed to proceed through copper-catalyzed tandem reaction of SNAr reaction, aerobic oxidation of C(sp3)-H bond and intramolecular C-N bond formation sequence. Structurally diverse 2-aryl, alkenyl and alkyl benzoimidazole derivatives were assembled by this methodology.
Microwave-assisted synthesis and biological evaluation of some benzimidazole derivatives containing a 1,2,4-Triazol Ring
Mentese, Emre,Karaali, Nesrin,Yimaz, Fatih,Uelker, Serdar,Kahveci, Bahittin
, p. 556 - 561 (2013/07/26)
A new series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique. This efficient procedure provides pure products within a few minutes. The newly synthesized compounds were confirmed by 1H NMR and 13C NMR spectra and they were screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity. A series of 2-(4-(trifluoromethyl)phenyl)-1H-benzo[d] imidazole derivatives containing a 1,2,4-triazole ring were synthesized via microwave technique and screened for their lipase inhibition and antioxidant activities. Compounds 4a, 4b, 5a, and 5b showed very good scavenging activity.
Citronellyl benzimidazoles
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, (2008/06/13)
Citronellyl benzimidazoles, e.g., (±) 1-(3,7-dimethyl-6-octen-1-yl)-2-phenylbenzimidazole, are prepared by reacting an alkali metal salt of a 2-phenylbenzimidazole with citronellyl halide and are useful as hypolipidemic agents.
