400073-79-2

Basic information

• Product Name: 2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-1,3-BENZIMIDAZOLE
• Synonyms: OTAVA-BB 1325788;4-(1H-Benzimidazol-2-yl)benzotrifluoride, 1-(1H-Benzimidazol-2-yl)-4-(trifluoromethyl)benzene;2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-1,3-BENZIMIDAZOLE
• CAS NO: 400073-79-2
• Molecular Formula: C14H9F3N2
• Molecular Weight: 262.23
• Mol File: 400073-79-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-1,3-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-1,3-BENZIMIDAZOLE(400073-79-2)
• EPA Substance Registry System: 2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-1,3-BENZIMIDAZOLE(400073-79-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 400073-79-2(Hazardous Substances Data)

Usage

Structure

benzimidazole derivative with a trifluoromethyl group attached to a phenyl ring

Pharmacological properties

studied for potential use as an antifungal and antibacterial agent, investigated for potential treatment of diseases such as cancer and inflammatory disorders

Trifluoromethyl group

known for enhancing biological activity and metabolic stability of pharmaceutical drugs

Potential applications

in medicine and pharmacology

Upstream product

• 15816-25-8 4-(trifluoromethyl)benzenimidic acid ethyl ester hydrochloride 
• 95-54-5 1,2-diamino-benzene 
• 615-43-0 2-iodophenylamine 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 1447946-58-8 5,6-diphenyl-3-(trifluoromethyl)benzo[4,5]imidazo[2,1-a]isoquinoline 

Relevant articles and documents

NOVEL SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHOD OF USE THEREOF

Novel soluble epoxide hydrolase (sEH) inhibitors are provided, along with methods for their use. The soluble epoxide hydrolase inhibitors are useful in treating and/or preventing sEH-related related diseases, such as Alzheimer's disease and inflammation.

Copper-Catalyzed Double C-N Bond Formation for the Synthesis of Diverse Benzimidazoles from N -Alkyl-2-iodoaniline and Sodium Azide

An efficient approach to the synthesis of benzimidazole derivatives has been achieved by copper-catalyzed double C-N bonds formation of N-alkyl-2-iodoaniline and sodium azide. The reaction was supposed to proceed through copper-catalyzed tandem reaction of SNAr reaction, aerobic oxidation of C(sp3)-H bond and intramolecular C-N bond formation sequence. Structurally diverse 2-aryl, alkenyl and alkyl benzoimidazole derivatives were assembled by this methodology.

Citronellyl benzimidazoles

Citronellyl benzimidazoles, e.g., (±) 1-(3,7-dimethyl-6-octen-1-yl)-2-phenylbenzimidazole, are prepared by reacting an alkali metal salt of a 2-phenylbenzimidazole with citronellyl halide and are useful as hypolipidemic agents.