400088-55-3

Basic information

• Product Name: 2-cyano-N-pyridin-4-ylacetamide
• Synonyms: 2-cyano-N-pyridin-4-ylacetamide
• CAS NO: 400088-55-3
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.16068
• Mol File: 400088-55-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-cyano-N-pyridin-4-ylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-N-pyridin-4-ylacetamide(400088-55-3)
• EPA Substance Registry System: 2-cyano-N-pyridin-4-ylacetamide(400088-55-3)

Safety Data

• Hazardous Substances Data: 400088-55-3(Hazardous Substances Data)

Upstream product

• 504-24-5 4-aminopyridine 
• 36140-83-7 1-cyanoacetyl-3,5-dimethylpyrazole 

Relevant articles and documents

Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides

The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2-b]pyrazole-7-carboxamides were investigated. Following a hit-to-lead optimization exploiting 2D and 3D cultures of MCF-7 human breast, 4T1 mammary gland, and HL-60 human promyelocytic leukemia cancer cell lines, a 67-membered library was constructed and the structure–activity relationship (SAR) was determined. Seven synthesized analogues exhibited sub-micromolar activities, from which compound 63 exerted the most significant potency with a remarkable HL-60 sensitivity (IC50 = 0.183 μM).