4002-83-9 Usage
Uses
Used in Organic Synthesis Industry:
1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE is used as a key intermediate in the synthesis of various organic compounds for different applications. Its unique structure and reactivity make it a valuable building block in the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE is used as a precursor in the synthesis of indazole-based derivatives for potential applications in medicinal chemistry. Its ability to form diverse chemical entities allows for the exploration of new therapeutic agents with improved pharmacological properties.
1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE is also used as a starting material in the preparation of dyes, pigments, and other colorants for various industries, such as textiles, plastics, and printing inks. Its light-sensitive nature and aromatic structure contribute to the color intensity and stability of the final products.
In the field of materials science, 1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE is utilized as a component in the design and synthesis of novel materials with specific properties, such as conductivity, magnetism, or luminescence. Its incorporation into polymers, nanoparticles, or other composites can lead to the development of advanced materials for various technological applications.
Proper handling and storage of 1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE are crucial due to its potential to emit toxic fumes upon decomposition when heated. Adhering to specified guidelines ensures the safety of personnel and the environment while working with 1-METHYL-1H-INDAZOLE-3-CARBALDEHYDE in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 4002-83-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,0 and 2 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4002-83:
(6*4)+(5*0)+(4*0)+(3*2)+(2*8)+(1*3)=49
49 % 10 = 9
So 4002-83-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c1-11-9-5-3-2-4-7(9)8(6-12)10-11/h2-6H,1H3
4002-83-9Relevant academic research and scientific papers
DEGRADERS AND DEGRONS FOR TARGETED PROTEIN DEGRADATION
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, (2019/06/05)
Pharmaceutical Degraders and Degrons for use in therapeutic applications are described herein.
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands
Ann, Jihyae,Czikora, Agnes,Saini, Amandeep S.,Zhou, Xiaoling,Mitchell, Gary A.,Lewin, Nancy E.,Peach, Megan L.,Blumberg, Peter M.,Lee, Jeewoo
supporting information, p. 6261 - 6276 (2018/06/11)
Diacylglycerol-lactones have proven to be a powerful template for the design of potent ligands targeting C1 domains, the recognition motif for the cellular second messenger diacylglycerol. A major objective has been to better understand the structure activity relations distinguishing the seven families of signaling proteins that contain such domains, of which the protein kinase C (PKC) and RasGRP families are of particular interest. Here, we synthesize a series of aryl- and alkyl-substituted diacylglycerol-lactones and probe their relative selectivities for RasGRP3 versus PKC. Compound 96 showed 73-fold selectivity relative to PKCα and 45-fold selectivity relative to PKC? for in vitro binding activity. Likewise, in intact cells, compound 96 induced Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation, a measure of PKCδ stimulation.
THERAPEUTIC AGENTS I
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Page/Page column 45-46, (2010/02/12)
Compounds of formula(I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders, and pharmaceutical compositions containing them.
