40029-36-5 Usage
Uses
Used in Pharmaceutical Industry:
(E)-2-CYANO-3-(3-PYRIDINYL)-2-PROPENAMIDE is used as a building block for the synthesis of various organic molecules and pharmaceutical drugs. Its unique structure contributes to the development of new therapeutic agents and medicines.
Used in Agrochemicals:
In the agrochemical industry, (E)-2-CYANO-3-(3-PYRIDINYL)-2-PROPENAMIDE may be utilized as a component in the creation of pesticides, herbicides, or other agricultural chemicals, enhancing their effectiveness and selectivity.
Used in Materials Science:
(E)-2-CYANO-3-(3-PYRIDINYL)-2-PROPENAMIDE's properties could also be harnessed in materials science for the development of novel materials with specific characteristics, such as improved stability or reactivity.
Safety Precautions:
It is crucial to handle (E)-2-CYANO-3-(3-PYRIDINYL)-2-PROPENAMIDE with care and follow proper safety protocols when working with (E)-2-CYANO-3-(3-PYRIDINYL)-2-PROPENAMIDE in a laboratory setting to ensure the safety of both the researchers and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 40029-36-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,0,2 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 40029-36:
(7*4)+(6*0)+(5*0)+(4*2)+(3*9)+(2*3)+(1*6)=75
75 % 10 = 5
So 40029-36-5 is a valid CAS Registry Number.
40029-36-5Relevant academic research and scientific papers
Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases
Nitsche, Christoph,Steuer, Christian,Klein, Christian D.
experimental part, p. 7318 - 7337 (2012/01/05)
The 3-aryl-2-cyanoacrylamide scaffold was designed as core pharmacophore for inhibitors of the Dengue and West Nile virus serine proteases (NS2B-NS3). A total of 86 analogs was prepared to study the structure-activity relationships in detail. Thereby, it turned out that the electron density of the aryl moiety and the central double bond have a crucial influence on the activity of the compounds, whereas the influence of substituents of the amide residue is less relevant. The para-hydroxy substituted analog was found to be the most potent inhibitor in this series with a Ki-value of 35.7 μM at the Dengue and 44.6 μM at the West Nile virus protease. The aprotinin competition assay demonstrates a direct interaction of the inhibitor molecule with active centre of the Dengue virus protease. The target selectivity was studied in a counterscreen with thrombin and found to be 2.8:1 in favor of DEN protease and 2.3:1 in favor of WNV protease, respectively.
